Angiotensin-Receptor Blockers and Risk of Alzheimer’s Disease in Hypertension Population – A Nationwide Cohort Study –

Chien-Yi Hsu; Chin-Chou Huang; Wan-Leong Chan; Po-Hsun Huang; Chia-Hung Chiang; Tzeng-Ji Chen; Chia-Min Chung; Shing-Jong Lin; Jaw-Wen Chen; Hsin-Bang Leu

doi:10.1253/circj.CJ-12-0658

Hypertension and Circulatory Control

Angiotensin-Receptor Blockers and Risk of Alzheimer’s Disease in Hypertension Population

– A Nationwide Cohort Study –

Chien-Yi Hsu, Chin-Chou Huang, Wan-Leong Chan, Po-Hsun Huang, Chia-Hung Chiang, Tzeng-Ji Chen, Chia-Min Chung, Shing-Jong Lin, Jaw-Wen Chen, Hsin-Bang Leu

Author information

Chien-Yi Hsu
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
Cardiovascular Research Center, National Yang-Ming University
Chin-Chou Huang
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
Department of Medical Research and Education, Taipei Veterans General Hospital
Cardiovascular Research Center, National Yang-Ming University
Wan-Leong Chan
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
Healthcare and Management Center, Taipei Veterans General Hospital
Po-Hsun Huang
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
Cardiovascular Research Center, National Yang-Ming University
Institute of Clinical Medicine, National Yang-Ming University
Chia-Hung Chiang
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
Cardiovascular Research Center, National Yang-Ming University
Institute of Clinical Medicine, National Yang-Ming University
Division of Cardiology, Department of Medicine, Zhudong Veterans Hospital
Tzeng-Ji Chen
Department of Family Medicine, Taipei Veterans General Hospital
Institute of Hospital and Health Care Administration, National Yang-Ming University
Chia-Min Chung
Institute of Biomedical Sciences, Academia Sinica
Shing-Jong Lin
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
Department of Medical Research and Education, Taipei Veterans General Hospital
Cardiovascular Research Center, National Yang-Ming University
Institute of Clinical Medicine, National Yang-Ming University
Jaw-Wen Chen
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
Department of Medical Research and Education, Taipei Veterans General Hospital
Cardiovascular Research Center, National Yang-Ming University
Institute of Pharmacology, National Yang-Ming University
Hsin-Bang Leu
Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital
Healthcare and Management Center, Taipei Veterans General Hospital
Cardiovascular Research Center, National Yang-Ming University
Institute of Clinical Medicine, National Yang-Ming University

Keywords: Angiotensin-receptor blockers, Alzheimer’s disease, Dementia, Hypertension, Taiwan National Health Insurance Research Database

JOURNAL FREE ACCESS
Supplementary material

2013 Volume 77 Issue 2 Pages 405-410

DOI https://doi.org/10.1253/circj.CJ-12-0658

Browse “Advance online publication” version

Details

Abstract

Background: Although emerging evidence shows angiotensin-receptor blockers (ARBs) may have a beneficial effect against Alzheimer’s disease (AD), the association is not consistent. We investigated the association between ARB use and the risk of development of AD using a nationwide, population-based cohort database in Taiwan. Methods and Results: In total, 16,426 newly diagnosed hypertensive patients who were administered ARB without a previous diagnosis of AD were identified from the Taiwan National Health Insurance database. The comparison group consisted of hypertensive patients who did not receive ARB, and were matched to exposed individuals using propensity score by enrolled time, age, sex, and comorbidities. During an average of 5.24±2.01 years of follow-up, a total of 1,031 cases (3.13%) of new AD occurred. The log-rank test showed no significant difference in the AD occurrence rate between subjects exposed to ARBs and non-exposed controls [488 (2.97%) vs. 543 (3.29%), P=0.221]. After adjusting for age, sex, comorbidities, and medications, only advanced age [hazard ratio (HR) 1.12, 95% confidence interval (CI) 1.12–1.13, P<0.001), female sex (HR 1.18, 95% CI 1.04–1.33, P=0.011), diabetes (HR 1.53, 95% CI 1.31–1.79, P<0.001), but not ARB (HR 1.08, 95% CI 0.96–1.22, P=0.222) were independently associated with AD development. Conclusions: The use of ARB was not significantly associated with a reduction of risk of AD in Asian patients with essential hypertension. (Circ J 2013; 77: 405–410)

Corresponding author

Register with J-STAGE for free!