JAPANESE CIRCULATION JOURNAL
Online ISSN : 1347-4839
Print ISSN : 0047-1828
ISSN-L : 0047-1828
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Simultaneous Elevation of the Levels of Circulating Monocyte Chemoattractant Protein-1 and Tissue Factor in Acute Coronary Syndromes
Koichi Nishiyama, Hisao Ogawa, Hirofumi Yasue, Hirofumi Soejima, Kenji Misumi, Keiji Takazoe, Michihiro Yoshimura, Kiyotaka Kugiyama, Ichiro Tsuji, Kousuke Kumeda
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Keywords: Acute coronary syndromes, Monocyte chemoattractant protein-1, Tissue factor
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1998 Volume 62 Issue 9 Pages 710-712

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Abstract

The levels of circulating monocyte chemoattractant protein-1 (MCP-1) and tissue factor (TF) were examined on admission in 46 consecutive patients with acute coronary syndromes (ACS) and 30 patients with stable exertional angina (SEA). The plasma levels of both MCP-1 and TF were higher in the ACS patients than in the SEA patients (MCP-1: p<0.001; TF: p<0.001). Only the circulating TF level related to the number of diseased vessels. A positive correlation between plasma MCP-1 and TF levels was found (r=0.476, p<0.001). These results suggest that circulating MCP-1 plays an important role in the pathogenesis and/or development of ACS. (Jpn Circ J 1998; 62: 710 - 712)

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© 1998 THE JAPANESE CIRCULATION SOCIETY
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The Nippon Journal of Clinical Angio-Cardiology

Japanese Circulation Journal

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Circulation Journal

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