Herb Formula “Fufangqishe-Pill” Prevents Upright Posture–Induced Intervertebral Disc Degeneration at the Lumbar in Rats

Qian-Qian Liang; Zhi-Jie Xi; Qin Bian; Xue-Jun Cui; Chen-Guang Li; Wei Hou; Qi Shi; Yong-Jun Wang

doi:10.1254/jphs.09231FP

Full Papers

Herb Formula “Fufangqishe-Pill” Prevents Upright Posture–Induced Intervertebral Disc Degeneration at the Lumbar in Rats

Qian-Qian Liang, Zhi-Jie Xi, Qin Bian, Xue-Jun Cui, Chen-Guang Li, Wei Hou, Qi Shi, Yong-Jun Wang

Author information

Qian-Qian Liang
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China
Institute of Spine, Shanghai University of Traditional Chinese Medicine, China
Zhi-Jie Xi
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China
Institute of Spine, Shanghai University of Traditional Chinese Medicine, China
Qin Bian
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China
Institute of Spine, Shanghai University of Traditional Chinese Medicine, China
Xue-Jun Cui
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China
Institute of Spine, Shanghai University of Traditional Chinese Medicine, China
Chen-Guang Li
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China
Institute of Spine, Shanghai University of Traditional Chinese Medicine, China
Wei Hou
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China
Institute of Spine, Shanghai University of Traditional Chinese Medicine, China
Qi Shi
Department of Orthopaedics & Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, China
Institute of Spine, Shanghai University of Traditional Chinese Medicine, China
Yong-Jun Wang
Institute of Spine, Shanghai University of Traditional Chinese Medicine, China

Keywords: chronic low back pain, Fufangqishe-Pill, lumbar intervertebral disc degeneration, extracellular matrix

JOURNAL FREE ACCESS

2010 Volume 113 Issue 1 Pages 23-31

DOI https://doi.org/10.1254/jphs.09231FP

Details

Abstract

Degeneration of the lumbar spine plays an important role in most chronic low back pain. Prevention of lumbar intervertebral disc (IVD) degeneration is therefore a high research priority. Both our previous multicenter clinical trials and pharmacological research showed that Fufangqishe-Pill (FFQSP), a newly patented traditional Chinese medicine, could effectively relieve the symptoms of neck pain and prevent cervical degeneration. To clarify the effect of FFQSP on lumbar IVD degeneration, we applied a lumbar IVD degeneration rat model induced by prolonged upright posture. Pretreatment of FFQSP for one month prevented the histological changes indicating IVD disorganization; increased type II–collagen level, decreased type X–collagen protein level, and increased Col2α1 mRNA expression at all time points; and decreased Col10α1, matrix metalloproteinase (MMP)-3, MMP13, and Interleukin (IL)-1β mRNA expression induced by upright posture for 7 and 9 months. These results suggest that FFQSP prevents lumbar IVD degeneration induced by upright posture. FFQSP is a promising medicine for lumbar IVD degeneration disease.

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