Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ12,14 Prostaglandin J2-Sensitive Microglial Activation

Kazuyuki Takata; Yoshihisa Kitamura; Masaaki Umeki; Daiju Tsuchiya; Jun-ichi Kakimura; Takashi Taniguchi; Peter J. Gebicke-Haerter; Shun Shimohama

doi:10.1254/jphs.91.330

Short Communications

Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ^12,14 Prostaglandin J₂-Sensitive Microglial Activation

Kazuyuki Takata, Yoshihisa Kitamura, Masaaki Umeki, Daiju Tsuchiya, Jun-ichi Kakimura, Takashi Taniguchi, Peter J. Gebicke-Haerter, Shun Shimohama

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Keywords: amyloid-β peptide, small oligomer, microglial activation

JOURNAL FREE ACCESS

2003 Volume 91 Issue 4 Pages 330-333

DOI https://doi.org/10.1254/jphs.91.330

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Abstract

In Alzheimer’s disease, fibrillar amyloid-β (Aβ) peptides form senile plaques associated with microglia. However, the relationship between Aβ peptides and microglia is not fully understood. In this study, the incubation of Aβ1-40 (Aβ40) produced small oligomers, while incubation with Aβ1-42 (Aβ42) caused large molecular aggregates. Microglial production of nitrite, interleukin-6 and tumor necrosis factor-α was induced by Aβ40, but not Aβ42. This production was significantly reduced by 15-deoxy-Δ^12,14 prostaglandin J₂, and it was completely suppressed by β-sheet breaker peptide, Leu-Pro-Phe-Phe-Asp. These results suggest that small oligomers, rather than large molecular aggregates, mediate microglial activation induced by Aβ peptides.

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