Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Species Difference in the Contribution of T-Type Calcium Current to Cardiac Pacemaking as Revealed by R(−)-Efonidipine
Hikaru Tanaka, Chisa Komikado, Iyuki Namekata, Hideki Nakamura, Mariko Suzuki, Yayoi Tsuneoka, Koki Shigenobu, Akira Takahara
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Keywords: R(−)-efonidipine, T-type Ca2+ current, cardiac pacemaking
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2008 Volume 107 Issue 1 Pages 99-102

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Abstract

The contribution of the T-type Ca2+ current to cardiac pacemaking was examined in isolated right atrial tissue from the mouse, guinea pig, and rabbit using a specific blocker, R(−)-efonidipine. At 10−6 M, R(−)-efonidipine produced negative chronotropy, which was prominent in the mouse and small but significant in the guinea pig. No effect was observed in the rabbit. Microelectrode recordings revealed that R(−)-efonidipine significantly prolongs the pacemaker (phase 4) depolarization of the sinoatrial-node action potential in the mouse and guinea pig. These results provide the first pharmacological evidence that the contribution of T-type Ca2+ current to cardiac pacemaking differs among experimental animal species.

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© The Japanese Pharmacological Society 2008
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