Regulatory RNAs derived from transfer RNA?

  1. Thoru Pederson1,2
  1. 1Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 USA
  2. 2Program in Cell and Developmental Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605 USA

Abstract

Four recent studies suggest that cleavages of transfer RNAs generate products with microRNA-like features, with some evidence of function. If their regulatory functions were to be confirmed, these newly revealed RNAs would add to the expanding repertoire of small noncoding RNAs and would also provide new perspectives on the coevolution of transfer RNA and messenger RNA.

Keywords

Footnotes

  • Reprint requests to: Thoru Pederson, Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA; e-mail: thoru.pederson{at}umassmed.edu; fax: (508) 856-8668.

  • Article published online ahead of print. Article and publication date are at http://www.rnajournal.org/cgi/doi/10.1261/rna.2266510.

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    1. Published in Advance August 18, 2010, doi: 10.1261/rna.2266510 RNA 16: 1865-1869 Copyright © 2010 RNA Society

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