Effect of Growth Hormone Treatment on Quality of Life in Japanese Children          with Growth Hormone Deficiency: An Analysis from a Prospective Observational          Study

Toshiaki Tanaka; Tomonobu Hasegawa; Keiichi Ozono; Hiroyuki Tanaka; Susumu Kanzaki; Susumu Yokoya; Kazuo Chihara; Noriyuki Iwamoto; Yoshiki Seino

doi:10.1297/cpe.23.83

Original Article

Effect of Growth Hormone Treatment on Quality of Life in Japanese Children with Growth Hormone Deficiency: An Analysis from a Prospective Observational Study

Toshiaki Tanaka, Tomonobu Hasegawa, Keiichi Ozono, Hiroyuki Tanaka, Susumu Kanzaki, Susumu Yokoya, Kazuo Chihara, Noriyuki Iwamoto, Yoshiki Seino

Author information

Toshiaki Tanaka
Tanaka Growth Clinic, Tokyo, Japan
Tomonobu Hasegawa
Department of Pediatrics, School of Medicine, Keio University, Tokyo, Japan
Keiichi Ozono
Department of Pediatrics, Graduate School of Medicine, Osaka University, Osaka, Japan
Hiroyuki Tanaka
Department of Pediatrics, Okayama Saiseikai General Hospital, Okayama, Japan
Susumu Kanzaki
Division of Pediatrics and Perinatology, Tottori University Faculty of Medicine, Tottori, Japan
Susumu Yokoya
Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, Japan
Kazuo Chihara
Hyogo Prefectural Kakogawa Medical Center, Kakogawa, Japan
Noriyuki Iwamoto
Medical Science, Eli Lilly Japan K.K., Kobe, Japan
Yoshiki Seino
Osaka Kosei-Nenkin Hospital, Osaka, Japan

Keywords: Child Behavior Checklist, GH deficiency, GH treatment, idiopathic short stature, Youth Self-Report

JOURNAL OPEN ACCESS

2014 Volume 23 Issue 3 Pages 83-92

DOI https://doi.org/10.1297/cpe.23.83

Details

Abstract

The aim of this study was to assess changes in quality of life (QoL) in Japanese children with GH deficiency (GHD) after 12 mo of GH treatment or with idiopathic short stature (ISS) after 12 mo without treatment. Children with GHD were treated with GH after enrollment. Outcome measures included the parent-rated Child Behavior Checklist (CBCL), the Youth Self-Report Form (YSR), and height standard deviation scores (SDS). Total CBCL scores significantly decreased in children with GHD (n = 152, mean change (standard deviation [SD]) = –3.42 [11.21]) and ISS (n = 129, mean change = –4.82 [10.09]) after 12 mo (p < 0.001). Total YSR scores (mean change = –9.21 [14.07]) and height SDS (mean change = 0.35 [0.38]) significantly decreased in children with GHD (p < 0.001), but were unchanged in children with ISS. The change in total YSR score was significantly correlated with the change in height SDS in children with GHD (r = –0.516, p = 0.003). Our findings demonstrate that GH treatment can improve QoL in Japanese children with GHD. The correlation between the changes in total YSR score and height SDS demonstrated that increased height resulted in improved QoL.

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