Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates

Authors

  • Juliana Alves dos Santos Departamento de Química, I.C.E., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil.
  • Roberta C. N. Reis Corrales Departamento de Química, I.C.E., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil.
  • Fernando R. Pavan Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, CEP 14801-902,Araraquara, SP, Brazil.
  • Clarice Queico. F. Leite Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, CEP 14801-902,Araraquara, SP, Brazil.
  • Rafael Mafra de Paula Dias Departamento de Química, I.C.E., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil.
  • Adilson David da Silva Departamento de Química, I.C.E., Universidade Federal de Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-900, Brazil.

DOI:

https://doi.org/10.13171/mjc.1.6.2012.02.05.15

Abstract

We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from D-glucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms.

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Published

2013-05-02

Issue

Vol. 1 No. 6 (2012)

Section

Bioinorganic Chemistry

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