Folia Parasitologica 52[4] 279-294 (2005) | DOI: 10.14411/fp.2005.039

Lyme borreliosis: insights into tick- / host-borrelia relations

Libor Grubhoffer1, Maryna Golovchenko1, Marie Vancová1, Klára Zacharovová-Slavíčková1, Nataliia Rudenko1, James H. Oliver Jr.2
1 Institute of Parasitology, Academy of Sciences of the Czech Republic and Faculty of Biological Sciences, University of South Bohemia, Branišovská 31, 370 05 České Budějovice, Czech Republic
2 Institute of Arthropodology and Parasitology, Georgia Southern University, Statesboro, Georgia 30460-8056, USA

Lyme borreliosis (LB) is a serious infectious disease of humans and some domestic animals in temperate regions of the Northern Hemisphere. It is caused by certain spirochetes in the Borrelia burgdorferi sensu lato (s.l.) species complex. The complex consists of 11 species (genospecies). Borrelia burgdorferi sensu stricto (s.s.), Borrelia garinii and Borrelia afzelii are the major agents of human disease. Borrelia burgdorferi s.l. species are transmitted mainly by ticks belonging to the Ixodes ricinus species complex plus a few additional species not currently assigned to the complex. B. burgdorferi infections may produce an acute or chronic disease with a wide array of clinical symptoms such as erythema migrans (EM), carditis, arthritis, neuroborreliosis, and acrodermatitis chronica atrophicans (ACA). Differences in LB spirochetes 'genospecies' and strains/isolates determine the occurrence and severity of this multi-system disease. Accurate and reliable identification of the LB spirochetes in ticks as well as knowledge of their prevalence are essential for prevention against the disease and development of an effective vaccine. An overview of the knowledge of molecular factors with emphasis on potential protein-carbohydrate interactions in the tick-borrelia system is the main focus of this review.

Keywords: borrelia spirochete, Lyme borreliosis, ticks, vectors, interactions, glycoproteins

Received: January 18, 2005; Accepted: June 23, 2005; Published: September 1, 2005  Show citation

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Grubhoffer, L., Golovchenko, M., Vancová, M., Zacharovová-Slavíčková, K., Rudenko, N., & Oliver, J.H. (2005). Lyme borreliosis: insights into tick- / host-borrelia relations. Folia Parasitologica, 52(4), 279-294. doi: 10.14411/fp.2005.039
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