Elevated cathepsin K potentiates metastasis of epithelial ovarian cancer
Xiujie Fan1, Chongjuan Wang2, Xianhui Song3, Huaqing Liu4, Xue Li5 and Yuanfang Zhang6
1The Medical Laboratory Diagnosis Center, Jinan Central Hospital Affiliated to Shandong University, Jinan, 2The Department of Gynecology, People's Hospital of Rizhao, Rizhao, 3The Department of Radiology, Zhangqiu District Hospital of Traditional Chinese Medicine, Jinan, 4Department of Neurology, The People's Hospital of Zhangqiu, Jinan, 5The Department of Health Care, The People's Hospital of Zhangqiu Area, Jinan and 6The Department of Obstetrics, People's Hospital of Weifang, Weifang, Shandong, P.R. China
Offprint requests to: Yuanfang Zhang, MD. The department of Obstetrics, People's Hospital of Weifang, Weifang, Shandong, 261000, P.R. China. e-mail: wfph_dryfzhang@163.com
Summary. Cathepsin K, or CTSK, has been found to be involved in the peritoneal metastasis of ovarian carcinoma. However, the expression and clinico-pathological significance of CTSK remains unknown in epithelial ovarian cancer (EOC). The aim of the present study was to investigate the expression of CTSK and its clinicopathological significance in EOC.
TSK expression was evaluated using immunohistochemistry in EOC tissue microarray. The expression of CTSK in EOC was displayed to be markedly higher than that of adjacent normal control. In addition, CSTK expression was shown to be remarkably associated with metastases and inferior overall prognosis of EOC. In vitro, Knock-down of CTSD was exhibited to be able to suppress migration and invasion in EOC cell lines OV-2008 but not proliferation in OV-2008. Together, our data showed that elevated CTSD in EOC can potentiate the metastasis of EOC cells, suggesting that targeting CTSD might be used as a novel therapeutic target for EOC. Histol Histopathol 33, 673-680 (2018)
Key words: Cathepsin K, Epithelial ovarian cancer, Migration, Invasion, Prognosis
DOI: 10.14670/HH-11-960