Use of Polymer-Supported Terpyridine Palladium Complex for Suzuki–Miyaura Cross-Coupling Reaction in Water and the Synthesis of 2,6-Disubstituted Pyrimidines

Toshimasa Suzuka; Mika Adachi; Zhong-Sheng Yang; Kazuhito Ogihara; Matsutake Higa

doi:10.14723/tmrsj.38.119

Regular Papers

Use of Polymer-Supported Terpyridine Palladium Complex for Suzuki–Miyaura Cross-Coupling Reaction in Water and the Synthesis of 2,6-Disubstituted Pyrimidines

Toshimasa Suzuka, Mika Adachi, Zhong-Sheng Yang, Kazuhito Ogihara, Matsutake Higa

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Keywords: cross coupling, terpyridine, pyrimidine, palladium

JOURNAL FREE ACCESS

2013 Volume 38 Issue 1 Pages 119-122

DOI https://doi.org/10.14723/tmrsj.38.119

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Abstract

In this study, a polymer-supported terpyridine–palladium complex was prepared and found to promote the Suzuki–Miyaura cross-coupling reaction in water. The terpyridine ligand was prepared from 4-methoxycarbonylbenzaldehyde, 2-acetylpyridine according to the reported procedures. The terpyridine ligand was immobilized onto a PS-PEG resin, and the complexation of the PS-PEG terpyridine ligand with Pd(II) gave the PS-PEG terpyridine–Pd(II) complex. The polymeric catalyst showed high catalytic activity and high reusability for this cross-coupling reaction. This catalyst was also applied to the synthesis of 2,6-disubstituted pyrimidines in water.

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