Effects of Ethyl Adenosine-5'-Carboxylate on the Heart and Coronary Circulation

Shoichi IMAI; Takeshi OTORII; Keisuke TAKEDA; Yumi KATANO; Daijiro HORII

doi:10.1536/ihj.16.421

Shoichi IMAI, Takeshi OTORII, Keisuke TAKEDA, Yumi KATANO, Daijiro HORII

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Keywords: Adenosine, Canine heart-lung preparation with a donor, Coronary circulation, Myocardial redox potential, Cardiac function, Aminophylline, Dipyridamole

JOURNAL FREE ACCESS

1975 Volume 16 Issue 4 Pages 421-432

DOI https://doi.org/10.1536/ihj.16.421

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Abstract

Using the canine heart-lung preparation supported by a donor, the effects of ethyl adenosine-5'-carboxylate (EAC) on the heart and coronary circulation were studied and compared with those of adenosine. EAC produced qualitatively similar effects to adenosine in this preparation. Aminophylline inhibited the effects of EAC as well as those of adenosine. Dipyridamole did not potentiate the effects of EAC, while it produced a definite potentiation of the effects of adenosine.

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