Journal of Pesticide Science
Online ISSN : 1349-0923
Print ISSN : 1348-589X
ISSN-L : 0385-1559
Original Articles
A rapid and sensitive analysis of dithiocarbamate fungicides using modified QuEChERS method and liquid chromatography–tandem mass spectrometry
Ayano KakitaniToshiaki YoshiokaYasushi NagatomiKoichi Harayama
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2017 Volume 42 Issue 4 Pages 145-150

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Abstract

We herein present a method for the analysis of 10 dithiocarbamate fungicides (DTCs) in beer, fruit juice, and malt samples, where the DTCs were converted into water-soluble sodium salts in the presence of NaHCO3 prior to methylation using dimethyl sulfate. Extraction of the methylated compounds from matrices was performed using a “quick, easy, cheap, effective, rugged, and safe” (QuEChERS) method. Following a dispersive solid-phase extraction as a clean-up step, the methylated compounds were detected by liquid chromatography-tandem mass spectrometry. Performance evaluation was carried out on beer, fruit juice, and malt samples using representative compounds. Accuracies of the spiked compounds from the various matrices ranged from 92.2 to 112.6%, and the limits of quantification of propineb, mancozeb, and thiuram were <0.52, <0.55, and <6.97 µg/kg, respectively. The developed method was then applied in the determination of dithiocarbamate fungicide contents in commercial beer and fruit juice samples.

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© 2017 Pesticide Science Society of Japan
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