[Purpose] The purpose of this study was to assess the quality of evidence for the efficacy of tendon and nerve gliding exercises in the management of carpal tunnel syndrome. [Subjects and Methods] Four electronic databases were searched to identify randomized controlled trials on the efficacy of tendon and nerve gliding exercises for carpal tunnel syndrome. Quality assessment was conducted using the Cochrane risk of bias tool. [Results] Four trials were identified and included in the review. The results of critical appraisal of quality ranged between low and moderate risk of bias. The available data could only be included as a narrative description. Symptom severity decreased and functional status improved with combined treatment, involving a tendon or nerve gliding exercise group plus conventional treatments, compared with the use of conventional treatments alone. [Conclusion] Evidence from 4 randomized controlled trials suggests that tendon and nerve gliding exercises, when combined with conventional treatments, may have a favorable effect in patients with carpal tunnel syndrome. However, further randomized controlled trials designed to assess the effect of tendon and nerve gliding exercises alone are required to investigate the hypothesis that such exercises alleviate carpal tunnel syndrome, and to confirm and further elucidate the efficacy of standardized physical exercise programs in patients with carpal tunnel syndrome.