Abstract
Salivary glad lysates of the sand fly Lutzomia longipalpis have been shown to enhance the infectivity of Leishmania in mice. As shown herein, the simultaneous inoculation of Leishmania chagasi stationary-phase promastigotes and L. longipalpis salivary gland by the intradermal route in a group of mongrel dogs induced a statistically significant eosinophilia, in relation to dogs inoculated with Leishmania or with salivary gland lysate only. These dogs had no evidence of infection, in spite of the infectivity of the promastigotes when inoculated by the intravenous route.
Leishmania chagasi; Lutzomia longipalpis; sand fly saliva; eosinophilia; infectivity; experimental infection; dogs
Development of Eosinophilia in dogs intradermically inoculated with sand fly saliva and Leishmania (Leishmania) chagasi stationary-phase promastigotes
Moacir Paranhos1
Washington C. dos Santos1
Italo Sherlock2
Geraldo G. S. Oliveira1
Lain C. Pontes de Carvalho1
FIOCRUZ, Centro de Pesquisas Gonçalo Moniz, Laboratório Avançado de Saúde Pública, Salvador, Brasil
FIOCRUZ, Centro de Pesquisas Gonçalo Moniz, Laboratório de Protozoologia, Salvador, Brasil
Salivary glad lysates of the sand fly Lutzomia longipalpis have been shown to enhance the infectivity of Leishmania in mice. As shown herein, the simultaneous inoculation of Leishmania chagasi stationary-phase promastigotes and L. longipalpis salivary gland by the intradermal route in a group of mongrel dogs induced a statistically significant eosinophilia, in relation to dogs inoculated with Leishmania or with salivary gland lysate only. These dogs had no evidence of infection, in spite of the infectivity of the promastigotes when inoculated by the intravenous route.
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Publication Dates
-
Publication in this collection
02 June 2009 -
Date of issue
June 1993
