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Contribution of education, occupation and cognitively stimulating activities to the formation of cognitive reserve

Contribuição da escolaridade, ocupação profissional e atividades cognitivamente estimulantes como variáveis formadoras da reserva cognitiva

Abstract

The cognitive reserve (CR) concept posits that there is individual variability in processing task demands and coping with neurodegenerative diseases. This variability can be attributed to the protective effects derived from continuous cognitive stimulation throughout life, including formal education, engagement in cognitively stimulating activities and occupation. These can result in protection against age-related cognitive decline and reduce the risk of developing Alzheimer's disease. The aim of this review is to summarize the main features of CR formation and to discuss the challenges in carrying out CR research in developing countries.

Key words:
cognitive reserve; aging; Alzheimer's disease; occupation attainment; schooling; cognitive stimulation.

Resumo

O conceito de Reserva Cognitiva (RC) postula que há variabilidades individuais no processamento de tarefas e no enfrentamento de doenças neurodegenerativas. Essa variabilidade pode se causada pela conseqüência do envolvimento em estimulações cognitivas sistemáticas ao longo da vida, tais como escolaridade, ocupação profissional e engajamento em atividades cognitivamente estimulantes; resultando na proteção contra os declínios cognitivos relacionados à idade e na diminuição do risco de desenvolver Doença de Alzheimer. O objetivo desta revisão é apresentar os principais fatores formadores de RC e discutir os desafios de realizar pesquisas sobre RC em países em desenvolvimento.

Palavras-chave:
reserva cognitiva; envelhecimento; Doença de Alzheimer; ocupação profissional; estimulação cognitiva.

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References

  • 1
    Stern Y. The concept of cognitive reserve: a catalyst for research. Yaakov Stern, editor. Cognitive Reserve. Theory and applications. New York: Taylor & Francis Group; 2007:1-4.
  • 2
    Katzman R, Terry R, DeTeresa R, et al. Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques. Ann Neurol 1988;23:138-144.
  • 3
    Stern Y. What is cognitive reserve? Theory and research application of the reserve concept. J Int Neuropsychol Soc 2002;8: 448-460.
  • 4
    Satz P. Brain reserve capacity on symptom onset after brain injury: a formulation and review of evidence for threshold theory. Neuropsychology 1993;7:273-295.
  • 5
    Staff RT, Murray AD, Deary IJ, Whalley, LJ. What provides cerebral reserve? Brain 2004;127:1191-1199.
  • 6
    Mortimer JA, Snowdon DA, Markesbery WR. Head circumference, education and risk of dementia: findings from the nun study. 2003;25:671-679.
  • 7
    Stern Y. Cognitive Reserve and Alzheimer Disease. Alzheimer Dis Assoc Disord 2006;20(Suppl. 2):S69-S74.
  • 8
    Stern Y, Habeck C, Moeller J, et al. Brain networks associated with cognitive reserve in healthy young and old adults. Cereb Cortex 2005;15:394-402.
  • 9
    Scarmeas N, Zarahn E, Anderson KE, et al. Cognitive reserve modulates functional brain responses during memory tasks: a PET study in healthy young and elderly subjects. Neuroimage 2003;19:1215-1227.
  • 10
    Rosen AC, Prull MW, O'Hara R, et al. Variable effects of aging on frontal lobe contributions to memory. Neuroreport 2002;13:2425-2428.
  • 11
    Grady CL, McIntosh AR, Beig S, Keightley ML, Burian H, Black SE. Evidence from functional Neuroimaging of a compensatory prefrontal network in Alzheimer's disease. J Neurosci 2003;23:986-993.
  • 12
    Cabeza R, Anderson ND, Locantore JK, McIntosh AR. Aging gracefully: compensatory brain activity in high-performancing older adults. Neuroimage 2002;17:1394-1402.
  • 13
    Scarmeas N, Stern Y. Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease. Curr Neurol Neurosci Rep 2004;4:374-380.
  • 14
    Alexander GE, Fuery ML, Grady CL GE, et al. Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis. Am J Psychiatry 1997;154:165-172.
  • 15
    Stern Y, Alexander GE, Prohovnik I, et al. Relationship between lifetime occupation and parietal flow: implications for a reserve against Alzheimer's disease pathology. Neurology 1995;45:55-60.
  • 16
    Stern Y, Alexander GE, Prohovnik I, Mayeux R. Inverse relationship between education and pariotemporal perfusion deficit in Alzheimer's disease. Ann Neurol 1992;32:371-375.
  • 17
    Kemppainen NM, Aalto S, Karrasch M, et al. Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease Ann Neurol 2008; 63:112-118.
  • 18
    Maguire EA, Gadian DG, Johnsrude IS, et al. Navigation-related structural change in the hippocampi of taxi drivers. Proc Natl Acad Sci (USA) 2000;97:4398-4403.
  • 19
    Maguire EA, Woollett K, Spiers HJ. London taxi drivers and bus drivers: a structural MRI and neuropsychological analysis. Hippocampus 2006;16:1091-1101.
  • 20
    Sole-Padullés C, Bartrés-Faz D, Junque C, et al. Brain structure and function related to cognitive reserve variables in normal aging, mild cognitive impairment and Alzheimer's disease. Neurobiol Aging 2007(in press).
  • 21
    Whalley LJ, Deary IJ, Appleton CL, Starr JM. Cognitive reserve and the neurobiology of cognitive aging. Ageing Res Rev 2004;3:369-382.
  • 22
    Deary IJ, Whalley IJ, Lemmon H, Crawford JR, Star JM. The stability of individual differences in mental ability from childhood to old age: follow-up of the 1932 Scottish Mental survey. Intelligence 2000;28:49-55.
  • 23
    Rabitt P, Lowe C. Patterns of cognitive ageing. Psychol Res 2006;63:308-316.
  • 24
    Kramer AF, Willis SL.Enhancing the cognitive ability of older adults. Curr Direc Psychol Science 2002;11:173-177.
  • 25
    Hultsch D, Hertzog C, Small Bj, Dixon RA. Use it or lose it: engaged lifestyle as a buffer of cognitive decline in aging? Psychol Aging 1999;14:245-263.
  • 26
    Salthouse TA. General and specific speed mediation of adult age differences in memory. J Gerontol Psychol Sci 1996;51B:P30-P42
  • 27
    West MJ. Regionally specific loss of neurons in the aging human hippocampus. Neurobiol Aging 1996;14:287-293.
  • 28
    Schretlen D, Pearlson GD, Anthony JA, et al. Elucidating the contributions of processing speed, executive ability, and frontal lobe volume to normal age-related differences in fluid intelligence. J Int Neuropsychol Soc 2000;6:52-61.
  • 29
    Buckner, RL. Memory and Executive Function in Aging and AD: Multiple factors that cause decline and reserve factors that compensate. Neuron 2004;44:195-208.
  • 30
    Raz N, Gunning FM, Head D, et al. Selective aging of the human cerebral cortex observed in vivo: differential vulnerability of the prefrontal gray matter. Cereb Cortex 1997;7:268-282.
  • 31
    Raz N. Aging of the brain and its impact on cognitive performance: integration of structural and functional findings. In: Craik FI, Salthouse TA, editores. Handbook of aging and cognition - II. Mahwah, NJ: Erlbaum; 2000.
  • 32
    De Carli C, Murphy DG, Gillette JA, et al. Lack of age-related differences in temporal lobe volume of very healthy adults. AJNR 1994;15:689-696.
  • 33
    Salat DH, Kaye JA, Janowsky JS. Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer disease. Arch Neurol 2001;58:1403-1408.
  • 34
    Good CD, Johnsrude IS, Ashburner J, Herson RN, Friston KJ, Frackowiak RS. A voxel-based morphometric study in ageing in 465 normal adult human brains. Neuroimage 2001;14:21-36.
  • 35
    Van Petten C, Plante E, Davidson PS, Kuo TY, Bajuscak L, Grisky EL. Memory and executive function in older adults: relationships with temporal and prefrontal gray matter volume and white matter hyperintensities. Neuropsychologia 2004;42:1313-1335.
  • 36
    Den Heijer T, Geerlings MI, Hoebeek FE, Hofman A, Koudstaal PJ, Breteler MMB. Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people. Arch Gen Psychiatry 2006;63:57-62.
  • 37
    Van Der Werf YD, Tisserand DJ, Visser PJ, et al. Thalamic volumes predicts performance on tests of cognitive speed and decreases in healthy aging. A magnetic resonance imaging- based volumetric analysis. Brain Res cogn Brain Res 2001;11:377-85.
  • 38
    Mattson MP, Chan SL, Duan W. Modification of brain aging and neurodegenerative disorders by genes, diet and behavior. Physiology 2002;82: 637-672.
  • 39
    Gage FH. Mammalian neural stem cells. Science 2000;287: 1433-1438.
  • 40
    Trachtenberg JT, Chen BE, Knott GW, et al. Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature 2002;420:788-794.
  • 41
    Kempermann G, Gast D, Gage FH. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long term environmental enrichment. Ann Neurol 2002;52: 135-143.
  • 42
    Lazarov O, Robinson J, Tang YP, et al. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell 2005;120:701-713.
  • 43
    LoGiudice, D. Dementia: an update to refresh your memory. Intern Med J 2002;32:535-540.
  • 44
    Nitrini R, Caramelli P, Herrera EJr, et al. Incidence of dementia in a community-dwelling Brazilian population. Alzheimer Dis Assoc Disord 2004;18:241-246.
  • 45
    Prince M. The need for research on dementia in developing countries. Trop Med Int Health 1997;2:993-1000.
  • 46
    Lopes MA, Bottino CMC. Prevalência de demência em diversas regiões do mundo. Análise dos estudos epidemiológicos de 1994 a 2000. Arq Neuropsiquiatr 2002;60:61-69.
  • 47
    Mangone CA, Arizaga RL. Dementia in Argentina and other Latin-American countries: an overview. Neuroepidemiology 1999;18:231-235.
  • 48
    Prince, M. The 10/66 Dementia Research Group. Dementia in developing countries. A Consensus statement from the 10/66 dementia research group. Int J Geriat Psychiatry 2000;15:14-20.
  • 49
    Herrera JR E, Caramelli P, Nitrini R. Estudo epidemiológico populacional de demência na cidade de Catanduva - estado de São Paulo- Brasil. Rev Psiq Clin 1998;25:70-73.
  • 50
    Herrera JE, Caramelli P, Silveira ASB, Nitrini R. Epidemiological survey of dementia in a community-dwelling Brazilian population. Alzheimer Dis Assoc Disord 2002;16:103-108.
  • 51
    Bottino, CMC. Prevalência de comprometimento cognitivo e demência em três distritos do município de São Paulo. Tese de Livre-docência. Departamento de Psiquiatria, Universidade de São Paulo;2007.
  • 52
    Gilleard CJ. Education and Alzheimer's disease: a review of recent international epidemiological studies. Aging Ment Health 1997;1:33-46.
  • 53
    Rosa TEC, Benício MHD, Latorre MRDO, Ramos LR. Fatores determinantes da capacidade funcional entre idosos. Rev Saude Publica 2003;37:40-48.
  • 54
    Geerlings MI, Deeg DJH, Schmand B, Lindboom J, Jonker C. Increased risk of mortality in Alzheimer's disease patients with higher education? A replication study. Neurology 1997;49:798-802.
  • 55
    Geerlings MI, Deeg DJH, Pennix BWJH, et al. Cognitive reserve and mortality in dementia: the role of cognition, functional ability and depression. Psychol Med 1999;29:1219-1226.
  • 56
    Stern Y, Albert S, Tang M-X, Tsai W-Y. Rate of memory decline in AD is related to education and occupation: Cognitive Reserve? Neurology 1999;45:1161-1168.
  • 57
    Wilson RS, Bennett DA, Gilley DW, Becket LA, Bames LL, Evans DA. Premorbid reading activity and patterns of cognitive decline in Alzheimer Disease. Arch Neurol 2000;57:1718-1723.
  • 58
    Scarmeas N, Albert SM, Manly JJ, Stern Y. Education and rates of cognitive decline in incident Alzheimer's disease. J Neurol Neurosurg Psychiatry 2006:77: 308-316.
  • 59
    Lee JH. Understanding cognitive reserve through genetics and genetic epidemiology. Yaakov Stern. Cognitive Reserve. Theory and applications. New York: Taylor & Francis Group, 2007:5-36.
  • 60
    Lyketsos CG, Chen LS, Anthony JC. Cognitive decline in adulthood: An 11.5-year follow-up of the Baltimore Epidemiologic Catchment Area study. Am J Psychiatry 1999;156: 58-65.
  • 61
    Starr JM, Deary IJ, Inch S. Blood pressure and cognitive decline in healthy old people. J Human Hypertens 1997;11:777-781.
  • 62
    Arbuckle TY, Maag U, Pushkar D, Chaikelson JS. Individual differences in trajectory of intellectual development over 45 years of adulthood. Psychol Aging 1998;13:663-675.
  • 63
    Christensen H, Korten AE, Jorm AF, et al. Education and decline in cognitive performance: Compensatory but not protective. Int J Geriatr Psychiatry 1997;12: 323-330.
  • 64
    Hototian SR, Lopes MA, Azevedo D, et al. Prevalence of cognitive and functional impairment in a community sample from São Paulo, Brazil. Dement Geriatr Cogn Disord 2008;25:135-143.
  • 65
    Le Carret N, Lafont S, Mayo W, Fabrigoule C. The effect of education on cognitive performances and its implication for the constitution of the cognitive reserve. Dev Neuropsychol 2003;23:317-337.
  • 66
    Ostrosky-Solis F, Ardila A, Rosselli M, Lopez-Arango G, Uriel-Mendoza V. Neuropsychological Test Performance in Illiterate Subjects. Arch Clin Neuropsychol 1998;18:645-660.
  • 67
    Alexander G, Furey ML, Grady CL, et al. Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: Implications for the cognitive reserve hypothesis. Am J Psychiatry 1997;154:165-172.
  • 68
    Manly JJ, Schupf N, Tang MX et al. Literacy and cognitive decline among ethnically diverse elders. In: Cognitive Reserve: Theory and Applications. New York: Taylor & Francis; 2007:219-235.
  • 69
    Manly JJ, Touradji P, Tang M-X, Stern Y. Literacy and memory decline among ethnically diverse elders. J Clin Exp Neuropsychol 2003;5:680-690.
  • 70
    Bennett DA, Wilson RS, Schneider JA, Evans DA, Mendes de Leon CF, Arnold SE. Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology 2003;60:1909-1915.
  • 71
    Evans DA, Hebert LE, Beckett LA, et al. Education and other measures of socioeconomic status and risk of incident Alzheimer's disease in a defined population of older persons. Arch Neurology 1997;54:1399-1405.
  • 72
    Katzman R. Education and prevalence of dementia and Alzheimer's disease. Neurology 1993;43:13-20.
  • 73
    Wilson RS, Bennett DA, Beckett LA, et al. Cognitive activity in older persons from a geographically defined population. J Gerontol B Psychol Sci Soc Sci 1999;54 B:155- 160.
  • 74
    Wilson RS, Barnes LL, Krueger KR, Hoganson G, Bienias JL, Bennett DA. Early and late life cognitive activity and cognitive systems in old age. J Int Neuropsychol Soc 2004;11:400-407.
  • 75
    Friedland RP, Fristch T, Smyth K, et al. Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members. PNAS 2001;98: 3440-3445.
  • 76
    Wilson RS, Mendes de Leon CF, Barnes LL, et al. Participation in cognitively stimulating activities and risk of incident Alzheimer disease. J Am Med Assoc 2002;287:742-748.
  • 77
    Hototian SR, Lopes MA, Bustamante SEZ, et al. Identification of dementia subjects in three districts of São Paulo city, Brazil. Int Psychogeriatr 2005;17(Suppl. 2):271-272.
  • 78
    Cerqueira ATAR. Deterioração cognitiva e depressão. In: Lebrão ML, Duarte YAO (org). O Projeto SABE no Município de São Paulo: uma abordagem inicial. Brasília: OPAS/MS; 2003:143-65.
  • 79
    Laks J, Batista EM, Guilherme ER, et al. Prevalence of cognitive and functional impairment in community-dwelling elderly: importance of evaluating activities of daily living. Arq Neuropsiquiatr 2005;63:207- 212.
  • 80
    Baldivia B, Bueno OFA. Influência da ocupação profissional na formação de Reserva Cognitiva de idosos saudáveis. Dissertação apresentada à Universidade Federal de São Paulo. São Paulo, 2008.
  • 81
    Salthouse TA. Disuse interpretations. In: TA Salthouse, editor. Theoretical perspectives on cognitive aging. Hillsdale, NJ, Lawrence Erlbaum Associates, Inc; 1991:173-223.
  • 82
    Helmer C, Letenneur L, Rouch I, et al. Occupation during life and risk of dementia in French elderly community residents. J Neurol Neurosurg Psychiatry 2001;7:303-309.
  • 83
    Schooler C, Mulatu MS, Oaetes G. Occupational self-direction, intellectual functioning, and self- directed orientation in older workers: findings and implications for individuals and societies. Am J Sociol 2004;110:161-167.
  • 84
    Stern N, Scarmeas N. Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease. Curr Neurol Neurosci Rep 2004;4:374-380.
  • 85
    Scarmeas N. Lifestyle patterns and cognitive reserve. Yaakov Stern. Cognitive Reserve. Theory and applications. New York: Taylor & Francis Group; 2007:187-206.
  • 86
    Dartigues JF, Gagnon M, Letenneur L, et al. Principal lifetime occupation and cognitive impairment in a French elderly cohort (Paquid). Am J Epidemiol 1992;135:981-988.
  • 87
    Andel R, Karholt I, Parker MG, Thorslund M, Gatz M. Complexity of primary lifetime occupation and cognition in advanced old age. J Aging Health 2007;19:397-415.
  • 88
    Li Chung- Yi, Wu SC, Sung F-C. Lifetime principal occupation and risk of cognitive impairment among the elderly. Industrial Health 2002;40:7-13.
  • 89
    Potter GG, Helms MJ, Plassman BL. Associations of job demands and intelligence with cognitive performance among men in late fife. Neurology 2008;70:1803-1808.
  • 90
    Stern Y, Gurland B, Tatemichi TK,Tang MX, Wilder D, Mayeux R. Influence of education and occupation on the incidence of Alzheimer's disease. J Am Med Assoc 1994;271:1004-1010.
  • 91
    Ansiau D, Marquié JC, Soubelet A, Ramos S. Relationships between cognitive characteristics of the job, age, and cognitive efficiency. Int Congress Serie 2005;1280:43-48.
  • 92
    Andel R, Vigen C, Mack WJ. The effect of education and occupational complexity on rate of cognitive decline in Alzheimer's patients. J Int Neuropsychol Soc 2006;12:147-152.
  • 93
    Karasek, RA. Job demands, job decision latitude, and mental strain: implications for job design. Adm Sci Q 1979;24:285-308.
  • 94
    TM, Graça CC, Araújo E. Estresse ocupacional e saúde: contribuições do Modelo Demanda-Controle. Cienc Saude Coletiva 2003;8:991-1003.
  • 95
    Schooler C, Mulatu MS, Oates G. Continuing effects of substantively complex work on the intellectual functioning of older workers. Psychol Aging 1999;147:483-506.
  • 96
    Bosma H, Van Voxtel MPJ, Pounds R, Houx P, Burdorf A, Jolles J. Mental work demands protect against cognitive impairment: MAAS prospective cohort study. Exp Aging Res 2003;29:33-45.
  • 97
    Jorm AF, Rodgers B, Henderson AS, et al. Occupation type as a predictor of cognitive decline and dementia in old age. Age Aging 1998;27:477-483.
  • 98
    Richards M, Deary J. A life course approach to cognitive reserve: a model for cognitive aging and development? Ann Neurol 2005;58:617-622.

Publication Dates

  • Publication in this collection
    Jul-Sep 2008

History

  • Received
    30 July 2008
  • Accepted
    20 Aug 2008
Academia Brasileira de Neurologia, Departamento de Neurologia Cognitiva e Envelhecimento R. Vergueiro, 1353 sl.1404 - Ed. Top Towers Offices, Torre Norte, São Paulo, SP, Brazil, CEP 04101-000, Tel.: +55 11 5084-9463 | +55 11 5083-3876 - São Paulo - SP - Brazil
E-mail: revistadementia@abneuro.org.br | demneuropsy@uol.com.br