Interleukin-6 and granulocyte macrophage-csf in the cerebrospinal fluid from hiv infected subjects with involvement of the central nervous system

Perrella, O.; Guerriero, M.; Izzo, E.; Soscia, M.; Carrieri, P. B.

doi:10.1590/S0004-282X1992000200008

Abstracts

We detected the cytokines interleukin-6 (IL-6) and granulocyte macrophage-CSF (GM-CSF) by ELISA in the CSF and serum of 30 HIV-infected patients classified as AIDS dementia complex (ADC), and 20 subjects with other neurological diseases (OND). We have found a high incidence of detectable IL-6 and GM-CSF in the CSF of ADC patients compared with OND patients. No statistical differences were observed between both groups for serum IL-6 and GM-CSF levels. These results suggest an intrathecal synthesis of these cytokines and a possible involvement in the pathogenesis of ADC.

AIDS dementia complex; cerebrospinal fluid; cytokines (interleukin-6, granulocyte-macrophage-CSF)

Detectamos as citocinas interleucina-6 (IL-6) e granulócito-macrófago-CSF (GM-CSF) por ELISA no LCR e soro de 30 pacientes infectados por HIV classificados como tendo AIDS-demência complexo (ADC) e de 20 pacientes com outras doenças neurológicas (OND). Encontramos elevada incidência de IL-6 e GM-CSF detectável no LCR de pacientes com ADC, em relação aos pacientes com OND. Diferenças estatísticas não foram observadas entre os dois grupos de pacientes para níveis de IL-6 e GM-CSF no soro. Esses resultados sugerem síntese intratecal dessas citocinas e sua possível participação na patogenia da ADC.

AIDS-demência complexo; líquido cefalorraquidiano; citocinas (interleucina-6, granulócito-macrófago-CSF)

O. Perrella^I; M. Guerriero^I; E. Izzo^I; M. Soscia^I; P. B. Carrieri^II

^ID. Cotugno Hospital for Infectious Diseases, Naples

^IIInstitute of Neurology, 2nd. Medical School, University of Naples

SUMMARY

We detected the cytokines interleukin-6 (IL-6) and granulocyte macrophage-CSF (GM-CSF) by ELISA in the CSF and serum of 30 HIV-infected patients classified as AIDS dementia complex (ADC), and 20 subjects with other neurological diseases (OND). We have found a high incidence of detectable IL-6 and GM-CSF in the CSF of ADC patients compared with OND patients. No statistical differences were observed between both groups for serum IL-6 and GM-CSF levels. These results suggest an intrathecal synthesis of these cytokines and a possible involvement in the pathogenesis of ADC.

Key words: AIDS dementia complex, cerebrospinal fluid, cytokines (interleukin-6, granulocyte-macrophage-CSF).

RESUMO

Detectamos as citocinas interleucina-6 (IL-6) e granulócito-macrófago-CSF (GM-CSF) por ELISA no LCR e soro de 30 pacientes infectados por HIV classificados como tendo AIDS-demência complexo (ADC) e de 20 pacientes com outras doenças neurológicas (OND). Encontramos elevada incidência de IL-6 e GM-CSF detectável no LCR de pacientes com ADC, em relação aos pacientes com OND. Diferenças estatísticas não foram observadas entre os dois grupos de pacientes para níveis de IL-6 e GM-CSF no soro. Esses resultados sugerem síntese intratecal dessas citocinas e sua possível participação na patogenia da ADC.

Palavras-chave: AIDS-demência complexo, líquido cefalorraquidiano, citocinas (interleucina-6, granulócito-macrófago-CSF).

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Acknowledgements The authors wish to thank the precious assistance and courtesy of Prof. Sergio Novis and Dr. Marzia Puccioni from the Department of Neurology, Federal University of Rio de Janeiro. This research was supported in part by grants from Ist. Sup. Sanità, Italy (Research contract 6203-004, AIDS Project).

Dr. Orestes Perrella Via E. A. Mario 35 - 80131 Napoli - Italia.

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