The Tohoku Journal of Experimental Medicine
Online ISSN : 1349-3329
Print ISSN : 0040-8727
ISSN-L : 0040-8727
Glutathione Reductase Activity in Serum and Liver Tissue of Human and Rat with Hepatic Damage
HIROKATSU KUMATAKAZUO WAKUIHIROSHI SUZUKITAKEHISA SUGAWARAINSU LIMMASAO OTSUKITSUNEO OZEKIKIYOMI MIURASHOICHI YAMAGATA
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1975 Volume 116 Issue 2 Pages 127-132

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Abstract

Glutathione reductase activity of both serum and liver tissue homogenates was measured in normal controls and in cases of hepatic parenchymatous diseases, and the results were compared with those from animal experiments in which hepatic damage was produced by CCl4 injection. Glutathione reductase showed a different attitude from those of transaminases and alkaline phosphatases under these clinical and experimental conditions. Glutathione reductase activity increased in both serum and liver in patients with hepatic damage, and this increase occurred earlier than the changes in alkaline phosphatase activity.

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