Anthelmintic Drug Discovery: Into the Future

Timothy G. Geary; Judy A. Sakanari; Conor R. Caffrey

doi:10.1645/14-703.1

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Timothy G. Geary,¹ Judy A. Sakanari,^1,* Conor R. Caffrey^1,**

¹Institute of Parasitology, McGill University, 21,111 Lakeshore Road, Ste. Anne de Bellevue, Quebec,

^*University of California San Francisco, Department of Pharmaceutical Chemistry, Byers Hall Room 508B, Campus Box 2550, 1700 4th Street, San Francisco, California 94158.
^**Center for Discovery and Innovation in Parasitic Diseases, Department of Pathology, University of California San Francisco, Byers Hall Room 501E, Campus Box 2550, 1700 4th Street, San Francisco, California 94158.

Abstract

The last half-century has provided all of the (few) drugs currently used to treat human helminthiases. Concern regarding the long-term utility of these drugs, given how readily resistance evolves in the veterinary-agricultural sector, spurs the discovery of new chemical entities. We review the approaches and technologies in use to identify anthelmintics and discuss a number of drug discovery paradigms that may prove pivotal to the next half-century of anthelmintic development.

Citation Download Citation

Timothy G. Geary, Judy A. Sakanari, and Conor R. Caffrey "Anthelmintic Drug Discovery: Into the Future," Journal of Parasitology 101(2), 125-133, (1 April 2015). https://doi.org/10.1645/14-703.1

Published: 1 April 2015

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