Welcome to International Journal of Anatomy and Research

Type of Article: Original Research

Year: 2016 | Volume 4 | Issue 2 | Page No. 2459-2463

Date of Publication: 30-06-2016

DOI: http://dx.doi.org/10.16965/ijar.2016.238

HEPATOPROTECTIVE EFFECT OF NIGELLA SATIVA SEED IN STERPTOZOTOCINE INDUCED DIABETIC ALBINO RATS: HISTOLOGICAL OBSERVATIONS

Shaik Hussain Saheb ^*1, Desai S D ², Kusal K Das ³, Haseena S⁴.

^*1 Ph.D Scholar, Department of Anatomy, Shri B M Patil Medical College Hospital & Research Centre, Bijapur and Assistant Professor in Anatomy, JJM Medical College, Davangere, Karnataka India.

² Principal, Shridevi Institute of Medical Sciences and Research Hospital, Tumkur, Karnataka, India.

³ Professor, Department of Physiology, Shri B M Patil Medical College Hospital & Research Centre, Bijapur, Karnataka, India.

⁴ Ph.D Scholar, Department of Physiology, Shri B M Patil Medical College Hospital & Research Centre, Bijapur and Lecturer in Physiology, JJM Medical College, Davangere, Karnataka India.

Address: Shaik Hussain Saheb, Assistant Professor in Anatomy, JJM Medical College, Davangere, Karnataka India. Mobile No.: +91-9242056660
E-Mail: anatomyshs@gmail.com

ABSTRACT

Background: Diabetes mellitus is associated with biochemical, physiological and pathological alterations in the liver.  Liver damage is associated with the formation of oxygen derived free radicals. Reactive oxygen species as well as nitrogen species are responsible for nuclear DNA fragmentation and cell death. The aim of this study was to investigate the hepatoprotective effects of Nigella sativa seed.
Materials and Methods: This work was conducted as part of Ph.D work under Department of Anatomy, Shri BM patil Medical College, BLDE University, Bijapur. University ethical committee and Institution Animal Ethical committee are approved the work according to CPCSEA (Govt of India) Rules. 18 rats were selected for this study and divided in to 3 groups each contains 6 rats, one group served as normal control, one group served as Streptozotocin (50mg/kg BW) induced diabetic control rats and one group served as diabetic rats treated with the nigella sativa seed powder(300mg/Kg body weight).
Results: Histopathological observations of present study showed that nigella sativa treatment has proved its hepatoprotective effect in streptozotocin induced diabetic rats. The liver enzyme parameters significant change also supported histopathological findings.
Conclusion: The results of present study concluding that Nigella sativa seed powder having hepatoprotective effect in streptozotocine induced diabetic rats.
Key Words: Hepatocytes, Nigella Sativa, Antioxidant, Nigella sativa, Thymoquinone.

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Shaik Hussain Saheb, Desai S D, Kusal K Das, Haseena S. HEPATOPROTECTIVE EFFECT OF NIGELLA SATIVA SEED IN STERPTOZOTOCINE INDUCED DIABETIC ALBINO RATS: HISTOLOGICAL OBSERVATIONS. Int J Anat Res 2016;4(2):2459-2463. DOI: 10.16965/ijar.2016.238