Czech J. Anim. Sci., 2021, 66(7):235-250 | DOI: 10.17221/163/2020-CJAS

Health traits in current dairy cattle breeding: A reviewReview

Ludmila Zavadilová ORCID...*, Eva Kašná, Zuzana Krupová, Anita Klímová
Institute of Animal Science, Prague-Uhříněves, Czech Republic

The review focuses on breeding practices aimed at improving resistance to diseases and health disorders that are associated with better efficiency, welfare and longevity of cows. It is commonly known that diseases like mastitis, foot and claw disorders, metabolic and reproductive issues seriously violate dairy cows' well-being. The cause of prevailing health and fertility deterioration has been the intensive selection merely based on higher milk production starting after the Second World War. Therefore since the last decades of the 20th-century genetic selection programs have been increasingly focused on increasing resistance to diseases and improving fertility traits using several omics techniques, including genomics. The first steps for maintaining the goal of genetic breeding for disease resistance were the introduction of disease data collection at national levels followed by an elaboration of gene evaluation systems. It was proved that diseases exhibit additive genetic variability exploitable in the breeding. For greater breeding efficiency, the indicator traits are used, which were strongly genetically correlated with health traits, have higher heritability, and above all, are usually easily measurable at low cost. Genome-wide association studies have identified several polymorphisms associated with disease liability that could also be used for speeding up selection efforts. Keywords: cow; clinical mastitis; foot and claw disease; metabolic disease; genomics.

Keywords: cow; clinical mastitis; foot and claw disease; metabolic disease; genomics

Published: July 1, 2021  Show citation

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Zavadilová L, Kašná E, Krupová Z, Klímová A. Health traits in current dairy cattle breeding: A review. Czech J. Anim. Sci.. 2021;66(7):235-250. doi: 10.17221/163/2020-CJAS.
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References

  1. Bastin C, Theron A, Laine A, Gengler N. On the role of midinfrared predicted phenotypes in fertility and health dairy breeding programs. J Dairy Sci. 2016 May 1;99(5):4080-94. Go to original source... Go to PubMed...
  2. Benedet A, Costa A, De Marchi M, Penasa M. Heritability estimates of predicted blood β-hydroxybutyrate and nonesterified fatty acids and relationships with milk traits in early-lactation Holstein cows. J Dairy Sci. 2020 Jul 1; 103(7):6354-63. Go to original source... Go to PubMed...
  3. Benzaquen ME, Risco CA, Archbald LF, Melendez P, Thatcher MJ, Thatcher WW. Rectal temperature, calving-related factors, and the incidence of puerperal metritis in postpartum dairy cows. J Dairy Sci. 2007 Jun 1;90(6):2804-14. Go to original source... Go to PubMed...
  4. Berry DP, Bermingham ML, Good M, More SJ. Genetics of animal health and disease in cattle. Ir Vet J. 2011 Dec; 64(5): 10 p. Go to original source... Go to PubMed...
  5. Bicalho RC, Vokey F, Erb HN, Guard CL. Visual locomotion scoring in the first seventy days in milk: Impact on pregnancy and survival. J Dairy Sci. 2007 Oct 1;90(10):4586-91. Go to original source... Go to PubMed...
  6. Cai Z, Guldbrandtsen B, Sando Lund M, Sahana G. Prioritizing candidate genes post-GWAS using multiple sources of data for mastitis resistance in dairy cattle. BMC Genomics. 2018 Dec;19(1): 11 p. Go to original source... Go to PubMed...
  7. Cha E, Hertl JA, Bar D, Grohn YT. The cost of different types of lameness in dairy cows calculated by dynamic programming. Prev Vet Med. 2010 Oct 1;97(1):1-8. Go to original source... Go to PubMed...
  8. Charfeddine N, Perez-Cabal MA. Effect of claw disorders on milk production, fertility, and longevity, and their economic impact in Spanish Holstein cows. J Dairy Sci. 2017 Jan 1;100(1):653-65. Go to original source... Go to PubMed...
  9. Costa A, Egger-Danner C, Meszaros G, Fuerst C, Penasa M, Solkner J, Fuerst-Waltl B. Genetic associations of lactose and its ratios to other milk solids with health traits in Austrian Fleckvieh cows. J Dairy Sci. 2019 May 1;102(5):4238-48. Go to original source... Go to PubMed...
  10. Costa A, Bovenhuis H, Penasa M. Changes in milk lactose content as indicators for longevity and udder health in Holstein cows. J Dairy Sci. 2020 Dec 1;103(12):11574-84. Go to original source... Go to PubMed...
  11. Daros RR, Eriksson HK, Weary DM, von Keyserlingk MAG. Lameness during the dry period: Epidemiology and associated factors. J Dairy Sci. 2019 Dec 1;102(12):11414-27. Go to original source... Go to PubMed...
  12. De Vries A, Marcondes M. Review: Overview of factors affecting productive lifespan of dairy cows. Animal. 2020 May;14(Suppl 1):s155-64. Go to original source... Go to PubMed...
  13. Dhakal K, Tiezzi F, Clay JS, Maltecca C. Inferring causal relationships between reproductive and metabolic health disorders and production traits in first-lactation US Holsteins using recursive models. J Dairy Sci. 2015 Apr 1; 98(4):2713-26. Go to original source... Go to PubMed...
  14. Egger-Danner C, Nielsen P, Fiedler A, Muller K, Fjeldaas T, Dopfer D, Daniel V, Bergsten C, Cramer G, Christen AM, Stock KF, Thomas G, Holzhauer M, Steiner A, Clarke J, Capion N, Charfeddine N, Pryce JE, Oakes E, Burgstaller J, Heringstad B, Odegard C, Kofler J, Egger F, Cole JB. ICAR claw health atlas. 1st ed. Rome (Italy): ICAR; 2015a. 45 p. (ICAR Technical Series).
  15. Egger-Danner C, Cole JB, Pryce JE, Gengler N, Heringstad B, Bradley A, Stock KF. Invited review: Overview of new traits and phenotyping strategies in dairy cattle with a focus on functional traits. Animal. 2015b Feb;9(2):191-207. Go to original source... Go to PubMed...
  16. Freebern E, Santos DJA, Fang L, Jiang J, Gaddis KLP, Liu GE, VanRaden PM, Maltecca C, Cole JB, Ma L. GWAS and fine-mapping of livability and six disease traits in Holstein cattle. BMC Genomics. 2020 Jan 13;21: 11 p. Go to original source... Go to PubMed...
  17. Fuerst-Waltl B, Fuerst C, Obritzhauser W, Egger-Danner C. Sustainable breeding objectives and possible selection response: Finding the balance between economics and breeders' preferences. J Dairy Sci. 2016 Dec 1;99 (12):9796-809. Go to original source... Go to PubMed...
  18. Georges M, Charlier C, Hayes B. Harnessing genomic information for livestock improvement. Nat Rev Genet. 2019 Mar;20(3):135-56. Go to original source... Go to PubMed...
  19. Gernand E, Koenig S. Genetic relationships among female fertility disorders, female fertility traits and productivity of Holstein dairy cows in the early lactation period. J Anim Breed Genet. 2017 Oct;134(5):353-63. Go to original source... Go to PubMed...
  20. Gernand E, Dohne DA, Koenig S. Genetic background of claw disorders in the course of lactation and their relationships with type traits. J Anim Breed Genet. 2013 Dec; 130(6):435-44. Go to original source... Go to PubMed...
  21. Gohary K, Overton MW, von Massow M, LeBlanc SJ, Lissemore KD, Duffield TF. The cost of a case of subclinical ketosis in Canadian dairy herds. Can Vet J. 2016 Jul;57 (7):728-32. Go to PubMed...
  22. Greenough PR. Bovine laminitis and lameness. 1st ed. Philadelphia (PA): Saunders Ltd.; 2007 Jun 21. 328 p.
  23. Guarini AR, Lourenco DAL, Brito LF, Sargolzaei M, Baes CF, Miglior F, Mizstal I, Schenkel FS. Genetics and genomics of reproductive disorders in Canadian Holstein cattle. J Dairy Sci. 2019 Feb 1;102(2):1341-53. Go to original source... Go to PubMed...
  24. Hailemariam D, Ibrahim S, Holelker M, Drillich M, Heuwieser W, Looft C, Cinar MU, Tholen E, Schellander K, Tesfaye D. MicroRNA-regulated molecular mechanism underlying bovine subclinical endometritis. Reprod Fertil Dev. 2014 Aug 7;26(6):898-913. Go to original source... Go to PubMed...
  25. Heikkila AM, Nousiainen JI, Pyorala S. Costs of clinical mastitis with special reference to premature culling. J Dairy Sci. 2012 Jan 1;95(1):139-50. Go to original source... Go to PubMed...
  26. Heringstad B. Genetic analysis of fertility-related diseases and disorders in Norwegian Red cows. J Dairy Sci. 2010; 93:2751-6. Go to original source... Go to PubMed...
  27. Heringstad B, Klemetsdal G, Ruane J. Responses to selection against clinical mastitis in the Norwegian cattle population. Acta Agric Scand A Anim Sci. 2001;51(2):155-60. Go to original source...
  28. Heringstad B, Chang YM, Gianola D, Klemetsdal G. Genetic analysis of clinical mastitis, milk fever, ketosis, and retained placenta in three lactations of Norwegian red cows. J Dairy Sci. 2005 Sep 1;88(9):3273-81. Go to original source... Go to PubMed...
  29. Heringstad B, Egger-Danner C, Charfeddine N, Pryce JE, Stock KF, Kofler J, Sogstad AM, Holzhauer M, Fiedler A, Müller K, Nielsen P, Thomas G, Gengler N, de Jong G, Odegard C, Malchiodi F, Miglior F, Alsaaod M, Cole JB. Invited review: Genetics and claw health: Opportunities to enhance claw health by genetic selection. J Dairy Sci. 2018 Jun 1;101(6):4801-21. Go to original source... Go to PubMed...
  30. Inlay MA, Bhattacharya D, Sahoo D, Serwold T, Seita J, Karsunky H, Plervitis SK, Dill DL, Weissman IL. Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes Dev. 2009 Oct 15;23(20):2376-81. Go to original source... Go to PubMed...
  31. Jamrozik J, Koeck A, Kistemaker GJ, Miglior F. Multipletrait estimates of genetic parameters for metabolic disease traits, fertility disorders, and their predictors in Canadian Holstein. J Dairy Sci. 2016;99(3):1990-8. Go to original source... Go to PubMed...
  32. Kasna E, Zavadilova L, Stipkova M. Genetic evaluation of clinical mastitis traits in Holstein cattle. Czech J Anim Sci. 2018 Nov 7;63(11):443-51. Go to original source...
  33. Kelton DF, Lissemore KD, Martin RE. Recommendations for recording and calculating the incidence of selected clinical diseases of dairy cattle. J Dairy Sci. 1998 Sep 1; 81(9):2502-9. Go to original source... Go to PubMed...
  34. Kock A, Fuerst-Waltl B, Kofler J, Burgstaller J, Steininger F, Fuerst C, Egger-Danner C. Short communication: Use of lameness scoring to genetically improve claw health in Austrian Fleckvieh, Brown Swiss, and Holstein cattle. J Dairy Sci. 2019 Feb 1;102(2):1397-401. Go to original source... Go to PubMed...
  35. Koeck A, Heringstad B, Egger-Danner C, Fuerst C, FuerstWaltl B. Comparison of different models for genetic analysis of clinical mastitis in Austrian Fleckvieh dualpurpose cows. J Dairy Sci. 2010a Sep 1;93(9):4351-8. Go to original source... Go to PubMed...
  36. Koeck A, Egger-Danner C, Fuerst C, Obritzhauer W, FuerstWaltl B. Genetic analysis of reproductive disorders and their relationship to fertility and milk yield in Austrian Fleckvieh dual purpose cows. J Dairy Sci. 2010b May 1; 93(5):2185-94. Go to original source... Go to PubMed...
  37. Koeck A, Miglior F, Kelton DF, Schenkel FS. Health recording in Canadian Holsteins: Data and genetic parameters. J Dairy Sci. 2012 Jul 1;95(7):4099-108. Go to original source... Go to PubMed...
  38. Koeck A, Jamrozik J, Schenkel F, Moore RK, Lefebvre DM, Kelton DF, Miglior F. Genetic analysis of milk β-hydroxybutyrate and its association with fat-to-protein ratio, body condition score, clinical ketosis, and displaced abomasum in early first lactation of Canadian Holstein. J Dairy Sci. 2014 Nov 1;97(11):7286-92. Go to original source... Go to PubMed...
  39. Koenig S, Sharifi AR, Wentrot H, Landmann D, Eise M, Simianer H. Genetic parameters of claw and foot disorders estimated with logistic models. J Dairy Sci. 2005 Sep 1;88(9):3316-25. Go to original source... Go to PubMed...
  40. Koivula M, Mantysaari EA, Negussie E, Serenius T. Genetic and phenotypic relationships among milk yield and somatic cell count before and after clinical mastitis. J Dairy Sci. 2005 Feb 1;88(2):827-33. Go to original source... Go to PubMed...
  41. Krpalkova L, Cabrera VE, Zavadilova L, Stipkova M. The importance of hoof health in dairy production. Czech J Anim Sci. 2019 Mar 13;64(3):107-17. Go to original source...
  42. Krupova Z, Krupa E, Michalickova M, Wolfova M, Kasarda R. Economic values for health and feed efficiency traits of dual-purpose cattle in marginal areas. J Dairy Sci. 2016 Jan 1;99(1):644-56. Go to original source... Go to PubMed...
  43. Krupova Z, Wolfova M, Krupa E, Pribyl J, Zavadilova L. Claw health and feed efficiency as new selection criteria in the Czech Holstein cattle. Czech J Anim Sci. 2018 Sep 27;63(10):408-18. Go to original source...
  44. Krupova Z, Zavadilova L, Wolfova M, Krupa E, Kasna E, Fleischer P. Udder and claw-related health traits in selection of Czech Holstein cows. Ann Anim Sci. 2019 Jul 1; 19(3):647-61. Go to original source...
  45. Liang D, Arnold LM, Stowe CJ, Harmon RJ, Bewley JM. Estimating US dairy clinical disease costs with a stochastic simulation model. J Dairy Sci. 2017 Feb 1;100(2):1472-86. Go to original source... Go to PubMed...
  46. Malchiodi F, Koeck A, Mason S, Christen AM, Kelton DF, Schenkel FS, Miglior F. Genetic parameters for hoof health traits estimated with linear and threshold models using alternative cohorts. J Dairy Sci. 2017;100(4):2828-36. Go to original source... Go to PubMed...
  47. Manske T, Hultgren J, Bergsten C. The effect of claw trimming on the hoof health of Swedish dairy cattle. Prev Vet Med. 2002 Jun 25;54(2):113-29. Go to original source... Go to PubMed...
  48. Martin P, Barkema HW, Brito LF, Narayana SG, Miglior F. Symposium review: Novel strategies to genetically improve mastitis resistance in dairy cattle. J Dairy Sci. 2018 Mar 1;101(3):2724-36. Go to original source... Go to PubMed...
  49. Martinez Y, Li X, Liu G, Bin P, Yan M, Mas D, Valdivie M, Hu CAA, Ren W, Yin Y. The role of methionine on metabolism, oxidative stress, and diseases. Amino Acids. 2017 Dec;49(12):2091-8. Go to original source... Go to PubMed...
  50. Miglior F, Fleming A, Malchiodi F, Brito LF, Martin P, Baes CF. A 100-year review: Identification and genetic selection of economically important traits in dairy cattle. J Dairy Sci. 2017 Dec 1;100(12):10251-71. Go to original source... Go to PubMed...
  51. Mostert PF, Bokkers EAM, van Middelaar CE, Hogeveen H, de Boer IJM. Estimating the economic impact of subclinical ketosis in dairy cattle using a dynamic stochastic simulation model. Animal. 2018 Jan 1;12(1):145-54. Go to original source... Go to PubMed...
  52. Nayeri S, Schenkel F, Fleming A, Kroezen V, Sargolzaei M, Baes C, Canovas A, Squires J, Miglior F. Genome-wide association analysis for β-hydroxybutyrate concentration in milk in Holstein dairy cattle. BMC Genetics. 2019 Dec;20(1): 7 p. Go to original source... Go to PubMed...
  53. Negussie E, Stranden I, Mantysaari EA. Genetic analysis of liability to clinical mastitis, with somatic cell score and production traits using bivariate threshold- linear and linear-linear models. Livest Sci. 2008 Aug 1; 117(1):52-9. Go to original source...
  54. Neuenschwander TFO, Miglior F, Jamrozik J, Berke O, Kelton DF, Schaeffer LR. Genetic parameters for producerrecorded health data in Canadian Holstein cattle. Animal. 2012 Jan 1;6(4):571-8. Go to original source... Go to PubMed...
  55. Odegard C, Svendsen M, Heringstad B. Genetic analyses of claw health in Norwegian Red cows. J Dairy Sci. 2013 Nov 1;96(11):7274-83. Go to original source... Go to PubMed...
  56. Oltenacu PA, Broom DM. The impact of genetic selection for increased milk yield on the welfare of dairy cows. Anim Welfare. 2010 May 1;19(1):39-49. Go to original source...
  57. Osteras O, Solbu H, Refsdal AO, Roalkvam T, Filseth O, Minsaas A. Results and evaluation of thirty years of health recordings in the Norwegian dairy cattle population. J Dairy Sci. 2007 Sep 1;90(9):4483-97. Go to original source... Go to PubMed...
  58. Parker Gaddis KL, Cole JB, Clay JS, Maltecca C. Incidence validation and relationship analysis of producer-recorded health event data from on-farm computer systems in the United States. J Dairy Sci. 2012 Sep 1;95(9):5422-35. Go to original source... Go to PubMed...
  59. Parker Gaddis KL, Megonigal JH Jr, Clay JS, Wolfe CW. Genome-wide association study for ketosis in US Jerseys using producer-recorded data. J Dairy Sci. 2018; 101(1):413-24. Go to original source... Go to PubMed...
  60. Perez-Cabal MA, Charfeddine N. Models for genetic evaluations of claw health traits in Spanish dairy cattle. J Dairy Sci. 2015 Nov 1;98(11):8186-94. Go to original source... Go to PubMed...
  61. Pfeiffer C, Fuerst C, Ducrocq V, Fuerst-Waltl B. Short communication: Genetic relationships between functional longevity and direct health traits in Austrian Fleckvieh cattle. J Dairy Sci. 2015 Oct 1;98(10):7380-3. Go to original source... Go to PubMed...
  62. Poppe M, Veerkamp RF, van Pelt ML, Mulder HA. Exploration of variance, autocorrelation, and skewness of deviations from lactation curves as resilience indicators for breeding. J Dairy Sci. 2020 Feb 1;103(2):1667-84. Go to original source... Go to PubMed...
  63. Pryce JE, Parker Gaddis KL, Koeck A, Bastin C, Abdelsayed M, Gengler N, Miglior F, Heringstad B, EggerDanner C, Stock KF, Bradley AJ, Cole JB. Invited review: Opportunities for genetic improvement of metabolic diseases. J Dairy Sci. 2016 Sep 1;99(9):6855-73. Go to original source... Go to PubMed...
  64. Rauw WM, Kanis E, Noordhuizen-Stassen EN, Grommers FJ. Undesirable side effects of selection for high production efficiency in farm animals: A review. Livest Prod Sci. 1998 Oct 1;56(1):15-33. Go to original source...
  65. Rollin E, Dhuyvetter KC, Overton MW. The cost of clinical mastitis in the first 30 days of lactation: An economic modeling tool. Prev Vet Med. 2015 Dec 1;122(3):257-64. Go to original source... Go to PubMed...
  66. Schaid DJ, Chen W, Larson NB. From genome-wide associations to candidate causal variants by statistical finemapping. Nat Rev Genet. 2018 Aug;19(8):491-504. Go to original source... Go to PubMed...
  67. Shabalina T, Yin T, Koenig S. Influence of common health disorders on the length of productive life and stayability in German Holstein cows. J Dairy Sci. 2020 Jan 1;103(1):583-96. Go to original source... Go to PubMed...
  68. Solano L, Barkema HW, Pajor EA, Mason S, LeBlanc SJ, Orsel K. Prevalence and distribution of foot lesions in dairy cattle in Alberta, Canada. J Dairy Sci. 2016 Aug 1;99(8):6828-41. Go to original source... Go to PubMed...
  69. Solbu H. Disease recording in Norwegian dairy cattle. I. Disease incidences and non-genetic effects on mastitis ketosis and milk fever. Z Tierzucht Zuechtungsbiol. 1983; 100(2):139-57. Go to original source...
  70. Tiezzi F, Parker-Gaddis KL, Cole JB, Clay JS, Maltecca C. A genome-wide association study for clinical mastitis in first parity US Holstein cows using single-step approach and genomic matrix re-weighting procedure. PLOS One. 2015 Feb 6;10(2): 15 p. Go to original source... Go to PubMed...
  71. Vacek M, Stadnik L, Stipkova M. Relationship between the incidence of health disorders and the reproduction traits of Holstein cows in the Czech Republic. Czech J Anim Sci. 2007 Aug 1;52(8):227-35. Go to original source...
  72. Van De Gucht T, Saeys W, Van Meensel J, Van Nuffel A, Vangeyte J, Lauwers L. Farm-specific economic value of automatic lameness detection systems in dairy cattle: From concepts to operational simulations. J Dairy Sci. 2018 Jan 1; 101(1):637-48. Go to original source... Go to PubMed...
  73. van der Spek D, van Arendonk JAM, Vallee AAA, Bovenhuis H. Genetic parameters for claw disorders and the effect of preselecting cows for trimming. J Dairy Sci. 2013 Sep 1;96(9):6070-8. Go to original source... Go to PubMed...
  74. van der Waaij EH, Holzhauer M, Ellen E, Kamphuis C, de Jong G. Genetic parameters for claw disorders in Dutch dairy cattle and correlations with conformation traits. J Dairy Sci. 2005 Oct 1;88(10):3672-8. Go to original source... Go to PubMed...
  75. Vazquez AI, Gianola D, Bates D, Weigel KA, Heringstad B. Assessment of Poisson logit and linear models for genetic analysis of clinical mastitis in Norwegian Red cows. J Dairy Sci. 2009 Feb 1;92(2):739-48. Go to original source... Go to PubMed...
  76. Vermunt JJ. One step closer to unravelling the pathophysiology of claw horn disruption: For the sake of the cows' welfare. Vet J. 2006 Dec 1;174(2):219-20. Go to original source... Go to PubMed...
  77. von Keyserlingk MAG, Barrientos A, Ito K, Galo E, Weary DM. Benchmarking cow comfort on North American freestall dairies: Lameness leg injuries lying time facility design and management for high-producing Holstein dairy cows. J Dairy Sci. 2012 Dec 1;95(12):7399-408. Go to original source... Go to PubMed...
  78. von Keyserlingk MAG, Martin NP, Kebreab E, Knowlton KF, Grant RJ, Stephenson M, Sniffen CJ, Harner JP, Wright AD, Smith SI. Invited review: Sustainability of the US dairy industry. J Dairy Sci. 2013 Sep 1;96(9):5405-25. Go to original source... Go to PubMed...
  79. Zavadilova L, Stipkova M, Svitakova A, Krupova Z, Kasna E. Genetic parameters for clinical mastitis, fertility and somatic cell score in Czech Holstein cattle. Ann Anim Sci. 2017 Oct 1;17(4):1007-18. Go to original source...
  80. Zwald NR, Weigel KA, Chang YM, Welper RD, Clay JS. Genetic selection for health traits using producer-recorded data. I. Incidence rates heritability estimates and sire breeding values. J Dairy Sci. 2004 Dec;87(12):4287-94. Go to original source... Go to PubMed...

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