Czech J. Food Sci., 2013, 31(1):5-13 | DOI: 10.17221/280/2011-CJFS

Antioxidant activity and mechanism of action of some synthesised phenolic acid amides of aromatic aminesOriginal Paper

Emma MARINOVA1, Lubomir GEORGIEV2, Iskra TOTSEVA1, Katya SEIZOVA1, Tsenka MILKOVA2
1 Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria
2 South-West University "Neofit Rilski", Blagoevgrad, Bulgaria

The antioxidative activities and mechanism of action were studied of eight synthesised cinnamoyl- and hydroxycinnamoyl amides of biogenic amines (caffeoyldopamine, cinnamoyldopamine, p-coumaroyldopamine, feruloyldopamine, sinapoyldopamine, caffeoylphenylethylamine, caffeoyltyramine, and caffeoyltryptamine) in a wide concentration range (2.5-20 × 10-4M) during autoxidation of triacylglycerols of sunflower oil. It was established that all amides exhibited excellent antioxidant activity, higher than or comparable with that of caffeic acid. The best activity was shown by caffeoyldopamine followed by cinnamoyldopamine and caffeoyltyramine. The analysis of the kinetic data obtained showed that the presence of hydroxyl groups in the amino part (derivatives of dopamine and tyramine) led to direct oxidation of the molecules during the process and stabilisation of the resulting radicals. In contrast, the amides without hydroxyl groups in the amino part participated in the side reaction with peroxides and the resulting radicals took part in one side reaction of the chain propagation as did caffeic acid.

Keywords: cinnamic acid derivatives; phenylpropenoyl amides of aromatic amines; triacylglycerols of sunflower oil

Published: February 28, 2013  Show citation

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MARINOVA E, GEORGIEV L, TOTSEVA I, SEIZOVA K, MILKOVA T. Antioxidant activity and mechanism of action of some synthesised phenolic acid amides of aromatic amines. Czech J. Food Sci.. 2013;31(1):5-13. doi: 10.17221/280/2011-CJFS.
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