Czech J. Food Sci., 2015, 33(1):1-7 | DOI: 10.17221/401/2014-CJFS

Ferulic acid in cereals - a reviewReview

Hüseyin BOZ
Department of Gastronomy and Culinary Arts, Tourism Faculty, Atatürk University Erzurum, Turkey

Phenolic acids represent the most common form of phenolic compounds in the cereal grain and many other plants. The phytochemical ferulic acid is found in the leaves and seeds of many plants, but especially in cereals. It is the most abundant phenolic acid in common cereals, representing up to 90% of total phenolic compounds. Ferulic acid has been reported to have many physiological functions, including antioxidant, antimicrobial, anti-inflammatory, and anti-cancer activities. It is an antioxidant which neutralises free radicals (superoxide, nitric oxide, and hydroxyl radical) which could cause oxidative damage to cell membranes and DNA. Like many other antioxidants, ferulic acid reduces the level of cholesterol and triglyceride, thereby reducing the risk of heart disease.

Keywords: bioactive compounds; phenolic acid; antioxidant; antimicrobial; whole grain

Published: February 28, 2015  Show citation

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BOZ H. Ferulic acid in cereals - a review. Czech J. Food Sci.. 2015;33(1):1-7. doi: 10.17221/401/2014-CJFS.
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    References

    1. Abdel-Aal E.S.M., Rabalski I. (2013): Effect of baking on free and bound phenolic acids in wholegrain bakery products. Journal of Cereal Science, 57: 312-318. Go to original source...
    2. Acosta-Estrada B.A., Lazo-Vélez M.A., Nava-Valdez Y., Gutiérrez-Uribe J.A., Serna-Saldívar S.O. (2014): Improvement of dietary fiber, ferulic acid and calcium contents in pan bread enriched with nejayote food additive from white maize (Zea mays). Journal of Cereal Science, 60: 264-269. Go to original source...
    3. Adom K.K., Liu R.H. (2002): Antioxidant activity of grains. Journal of Agricultural and Food Chemistry, 50: 6182-6187. Go to original source... Go to PubMed...
    4. Andreasan M.F., Kroon P.A., Williamson G., Garcia-Conesa M.T. (2001): Intestinal release and uptake of phenolic antioxidant diferulic acids. Free Radical Biology & Medicine, 31: 304-314. Go to original source... Go to PubMed...
    5. Anson N.M., van den Berg R., Havenaar R., Bast A., Haenen G.R.M.M. (2009): Bioavailability of ferulic acid is determined by its bioaccessibility. Journal of Cereal Science, 49: 296-300. Go to original source...
    6. Arranz S., Silvan M.J., Saura-Calixto F. (2010): Nonextractable polyphenols, usually ignored, are the major part of dietary polyphenols: A study on the Spanish diet. Molecular Nutrition and Food Research, 54: 1646-1658. Go to original source... Go to PubMed...
    7. Aturki Z., Fanali S., D'orazio G., Rocco A., Rosati C. (2008): Analysis of phenolic compounds in extra virgin olive oil by using reversed-phase capillary electrochromatography. Electrophoresis, 29: 1643-1650. Go to original source... Go to PubMed...
    8. Belobrajdic D.P., Bird A. (2013): The potential role of phytochemicals in wholegrain cereals for the prevention of type-2 diabetes. Nutrition Journal, 12: 62. Go to original source... Go to PubMed...
    9. Bondia-Pons I., Aura A.M., Vuorela S., Kolehmainen M., Mykkanen H., Poutanen K. (2009): Rye phenolics in nutrition and health. Journal of Cereal Science, 49: 323-336. Go to original source...
    10. Bourne L.C., Rice-Evans C. (1998): Bioavailability of ferulic acid. Biochemical and Biophysical Research Communications, 253: 222-227. Go to original source... Go to PubMed...
    11. Bunzel M., Ralph J., Marita J.M., Hatfield R.D., Steinhar H. (2001): Diferulates as structural components in soluble and insoluble cereal dietary fibre. Journal of the Science of Food and Agriculture, 81: 653-660. Go to original source...
    12. Coghe S., Benoot K., Delvaux F., Vanderhaegen B., Delvaux F.R. (2004): Ferulic acid release and 4-vinylguaiacol formation during brewing and fermentation: Indications for feruloyl esterase activity in Saccharomyces cerevisiae. Journal of Agriculture and Food Chemistry, 52: 602-608. Go to original source... Go to PubMed...
    13. Dai J., Mumper R.J. (2010): Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules, 15: 7313-7352. Go to original source... Go to PubMed...
    14. Fazary A.E., Ju Y.H. (2007): Feruloyl esterases as biotechnological tools: current and future perspectives. Acta Biochimica et Biophysica Sinica, 39: 811-828. Go to original source... Go to PubMed...
    15. Ferguson L.R., Lim I.F., Pearson A.E., Ralph J., Harris P.J. (2003): Bacterial antimutagenesis by hydroxycinnamic acids from plant cell walls. Mutation Research, 542: 49-58. Go to original source... Go to PubMed...
    16. Finocchiaro F., Ferrari B., Gianinetti A., Dall'asta C., Galaverna G., Scazzina F., Pellegrini N. (2007): Characterization of antioxidant compounds of red and white rice and changes in total antioxidant capacity during processing. Molecular Nutrition & Food Research, 51: 1006-1019. Go to original source... Go to PubMed...
    17. Gani A., Wani S.M., Masoodi F.A., Hameed G. (2012): Wholegrain cereal bioactive compounds and their health benefits. Journal of Food Processing & Technology, 3: 146. Go to original source...
    18. Garcia R., Rakotozafy L., Telef N., Potus J., Nicolas J. (2002): Oxidation of ferulic acid or arabinose-esterified ferulic acid by wheat germ peroxidase. Journal of Agriculture and Food Chemistry, 50: 3290-3298. Go to original source... Go to PubMed...
    19. Graf E. (1992): Antioxidant potential of ferulic acid. Free Radical Biology & Medicine, 13: 435-448. Go to original source... Go to PubMed...
    20. Guo W., Beta T. (2013): Phenolic acid composition and antioxidant potential of insoluble and soluble dietary fibre extracts derived from select whole-grain cereals. Food Research International, 51: 518-525. Go to original source...
    21. Hahn D.H., Faubion J.M., Rooney L.W. (1983): Sorghum phenolic acids, their high performance liquid chromatography separation and their relation to fungal resistance. Cereal Chemistry, 60: 255-259.
    22. Hingse S.S., Digole S.B., Annapure U.S. (2014): Method development for simultaneous detection of ferulic acid and vanillin using high-performance thin layer chromatography. Journal of Analytical Science and Technology, 5: 21. Go to original source...
    23. Holtekjolen A.K., Baevre A.B., Rodbotten M., Berg H., Knutsen S.H. (2008): Antioxidant properties and sensory profiles of breads containing barley flour. Food Chemistry, 110: 414-421. Go to original source... Go to PubMed...
    24. Hübner F., Arendt E.K. (2013): Germination of cereal grains as a way to improve the nutritional value: a review. Critical Reviews in Food Science and Nutrition, 53: 853-861. Go to original source... Go to PubMed...
    25. Itagaki S., Kurokawa T., Nakata C., Saito Y., Oikawa S., Kobayashi M., Hirano T., Iseki K. (2009): In vitro and in vivo antioxidant properties of ferulic acid: a comparative study with other natural oxidation inhibitors. Food Chemistry, 114: 466-471. Go to original source...
    26. Jeong Y.C., Jae H.M., Keun H.P. (2000): Isolation and identification of 3-methoxy-4-hydroxybenzoic acid and 3-methoxy-4hydroxycinnamic acid from hot water extracts of Hovenia dulcis Thumb and confirmation of their antioxidative and antimicrobial activity. Korean Journal of Food Science and Technology, 32: 1403-1408.
    27. Jilek M.L., Bunzel M. (2013): Dehydrotriferulic and dehydrodiferulic acid profiles of cereal and pseudocereal flours. Cereal Chemistry, 90: 507-514. Go to original source...
    28. Kalt W. (2005): Effects of production and processing factors on major fruit and vegetable antioxidants. Journal of Food Science, 70: R11-R19. Go to original source...
    29. Kandil A., Li J., Vasanthan T., Bressler D.C. (2005): Phenolic acids in some cereal grains and their inhibitory effect on starch liquefaction and saccharification. Journal of Agriculture and Food Chemistry, 60: 8444-8449. Go to original source... Go to PubMed...
    30. Karamaæ M., Bucinski A., Pegg R.B., Amarowicz R. (2005): Antioxidant and antiradical activity of ferulates. Czech Journal of Food Sciences, 23: 64-68. Go to original source...
    31. Katina K., Laitila A., Juvonen R., Liukkonen K-H., Kariluoto S., Piironen V., Landberg R., Åman P., Poutanen K. (2007): Bran fermentation as a means to enhance technological properties and bioactivity of rye. Food Microbiology, 24: 175-186. Go to original source... Go to PubMed...
    32. Kern S.M., Bennett R.N., Mellon F.A., Kroon P.A., GarciaConesa M.T. (2003): Absorption of hydroxycinnamates in humans after high bran cereal consumption. Journal of Agriculture and Food Chemistry, 51: 6050-6055. Go to original source... Go to PubMed...
    33. Kim K.H., Tsao R., Yang R., Cui S.W. (2006): Phenolic acid profiles and antioxidant activities of wheat bran extracts and the effect of hydrolysis conditions. Food Chemistry, 95: 466-473. Go to original source...
    34. Kim M.J., Hyun J.N., Park J.C., Kim J.G., Lee S.J., Chun S.C., Chung I.M. (2007): Relation between phenolic compounds, anthocyanins content and antioxidant activity in colored barley germplasm. Journal of Agricultural and Food Chemistry, 55: 4802-4809. Go to original source... Go to PubMed...
    35. Kováèová M., Malinová E. (2007): Ferulic and coumaric acids, total phenolic compounds and their correlation in selected oat genotypes. Czech Journal of Food Sciences, 25: 325-332. Go to original source...
    36. Kroon P.A., Faulds C.B., Ryden P., Robertson J.S., Williamson G. (1997): Release of covalently bound ferulic acid from fiber in the human colon. Journal of Agriculture and Food Chemistry, 45: 661-667. Go to original source...
    37. Kroon P.A., Williamson G. (1999): Hydroxycinnamates in plants and food: current and future perspectives. Journal of the Science of Food and Agriculture, 79: 355-361. Go to original source...
    38. Ktenioudaki A., Alverez-Jubate L., Gallagher E. (2014): A review of the process-induced changes in the phytochemical content of cereal grains: The bread making process. Critical Reviews in Food Science and Nutrition, 55: 611-619. Go to original source... Go to PubMed...
    39. Kuenzig W., Chau J., Norkus E., Holowaschenko H., Mergens W., Conney A.H. (1984): Caffeic and ferulic acid as blockers of nitrosamine formation. Carcinogenesis, 5: 309-313. Go to original source... Go to PubMed...
    40. Laokuldilok T., Shoemaker C.F., Jongkaewwattana S., Tulyathan V. (2011): Antioxidants and antioxidant activity of several pigmented rice brans. Journal of Agriculture and Food Chemistry, 59: 193-199. Go to original source... Go to PubMed...
    41. Lin F.H., Lin J.Y., Gupta R.D., Tournas J.A., Burch J.A., Selim M.A., Monteiro-Riviere N.A., Grichnik J.M., Zielinski J., Pinnell S.R. (2005): Ferulic acid stabilizes a solution of vitamins C and E and doubles its photoprotection of skin. Journal of Investigative Dermatology, 125: 826-832. Go to original source... Go to PubMed...
    42. Liu R.H. (2007): Whole grain phytochemicals and health. Journal of Cereal Science, 46: 207-219. Go to original source...
    43. Lo H.H., Chung J.G. (1999): The effects of plant phenolics, caffeic acid, chlorogenic acid and ferulic acid on arylamine N-acetyltransferase activities in human gastrointestinal microflora. Anticancer Research, 19:133-139.
    44. Manach C., Scalbert A., Morand C., Rémésy C., Jiménez L. (2004): Polyphenols: food sources and bioavailability. The American Journal of Clinical Nutrition, 79: 727-747. Go to original source... Go to PubMed...
    45. Marinova E.M., Yanishlieva N.V. (1992): Effect of temperature on the antioxidative action of inhibitors in lipid autoxidation. Journal of the Science of Food and Agriculture, 60: 313-318. Go to original source...
    46. Mathew S., Abraham T.E. (2004): Ferulic acid: an antioxidant found naturally in plant cell walls and feruloyl esterases involved in its release and their applications. Critical Reviews in Biotechnology, 24: 59-83. Go to original source... Go to PubMed...
    47. Mattila P., Pihlava J.M., Hellstrom J. (2005): Contents of phenolic acids, alkyl- and alkenylresorcinols, and avenanthramides in commercial grain products. Journal of Agricultural and Food Chemistry, 53: 8290-8295. Go to original source... Go to PubMed...
    48. Moore J., Luther M., Cheng Z., Yu L.L. (2009): Effects of baking conditions, dough fermentation, and bran particle size on antioxidant properties of whole-wheat pizza crusts. Journal of Agriculture and Food Chemistry, 57: 832-839. Go to original source... Go to PubMed...
    49. Mori H., Kawabata K., Yoshimi N., Tanaka T., Murakami T., Okada T., Murai H. (1999): Chemopreventive effects of ferulic acid on oral and rice germ on large bowel carcinogenesis. Anticancer Research, 19: 3775-3778.
    50. Napolitano A., Costabile A., Martin-Pelaez S., Vitaglione P., Klinder A., Gibson G.R., Fogliano V. (2009): Potential prebiotic activity of oligosaccharides obtained by enzymatic conversion of durum wheat in soluble dietary fibre into soluble dietary fibre. Nutrition, Metabolism & Cardiovascular Diseases, 19: 283-290. Go to original source... Go to PubMed...
    51. Ndolo V.U., Beta T. (2014): Comparative studies on composition and distribution of phenolic acids in cereal grain botanical fractions. Journal of Cereal Chemistry, 91: 522-530. Go to original source...
    52. Ndolo V.U., Beta T., Fulcher R.G. (2013): Ferulic acid fluorescence intensity profiles and concentration measured by HPLC in pigmented and non-pigmented cereals. Food Research International, 52: 109-118. Go to original source...
    53. Ou S., Kwok K.C. (2004): Ferulic acid: Pharmaceutical functions, preparation and applications in foods. Journal of the Science of Food and Agriculture, 84: 1261-1269. Go to original source...
    54. Prasad N.R., Ramachandran S., Pugalendi K.V., Menon V.P. (2007): Ferulic acid inhibits UV-B-induced oxidative stress in human lymphocytes. Nutrition Research, 27: 559-564. Go to original source...
    55. Price R.K., Welch R.W., Lee-Manion A.M., Bradbury I., Strain J.J. (2008): Total phenolics and antioxidant potential in plasma and urine of humans after consumption of wheat bran. Cereal Chemistry, 85: 152-157. Go to original source...
    56. Ralph J., Quideau S., Grabber J.H., Hatfield R.D. (1994): Identification and synthesis of new ferulic acid dehydrodimers present in grass cell walls. Journal of the Chemical Society, 1: 3485-3498. Go to original source...
    57. Réblová Z. (2012): Effect of temperature on the antioxidant activity of phenolic acids. Czech Journal of Food Sciences, 30: 171-177. Go to original source...
    58. Rice-Evans C.A., Miller N.J., Paganga G. (1996): Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radical Biology and Medicine, 20: 933-956. Go to original source... Go to PubMed...
    59. Rocha L.D., Monteiro M.C., Teodoro A.J. (2012): Anticancer properties of hydroxycinnamic acids - a review. Cancer and Clinical Oncology, 1: 109-121. Go to original source...
    60. Shahidi F., Chandrasekara A. (2010): Hydroxycinnamates and their in vitro and in vivo antioxidant activities. Phytochemistry Reviews, 9: 147-170. Go to original source...
    61. Shahidi F., Chandrasekara A. (2013): Millet grain phenolics and their role in disease risk reduction and health promotion: a review. Journal of Functional Foods, 5: 570-581. Go to original source...
    62. Sharma O.P., Bhat T.K., Singh B. (1998): Thin-layer chromatography of gallic acid, methyl gallate, pyrogallol, phloroglucinol, catechol, resorcinol, hydroquinone, catechin, epicatechin, cinnamic acid, p-coumaric acid, ferulic acid and tannic acid. Journal of Chromatography A, 822: 167-171. Go to original source...
    63. Sharma U.K., Sharma N., Gupta A.P., Kumar V., Sinha A.K. (2007): RP-HPTLC densitometric determination and validation of vanillin and related phenolic compounds in accelerated solvent extract of Vanilla planifolia. Journal of Separation Science, 30: 3174-3180. Go to original source... Go to PubMed...
    64. Singh A.K., Rehal J., Kaur A., Jyot G. (2013): Enhancement of attributes of cereals by germination and fermentation: a review. Critical Reviews in Food Science and Nutrition. doi: 10.1080/10408398.2012.706661. Go to original source... Go to PubMed...
    65. Smith M.M., Hartley R.D. (1983): Occurrence and nature of ferulic acid substitution of cell-wall polysaccharides in graminaceous plants. Carbohydrate Research, 118: 65-80. Go to original source...
    66. Srinivasan M., Sudheer A.R., Menon V.P. (2007): Ferulic acid: therapeutic potential through its antioxidant property. Journal of Clinical Biochemistry and Nutrition, 40: 92-100. Go to original source... Go to PubMed...
    67. Tee-ngam P., Nunant N., Rattanarant P., Siangproh W., Chailapakul O. (2013): Simple and rapid determination of ferulic acid levels in food and cosmetic samples using paperbased platforms. Sensors, 13: 13039-13053. Go to original source... Go to PubMed...
    68. Teixeria J., Gaspar A., Garrido E.M., Garrido J., Borges F. (2013): Hydroxycinnamic acid antioxidants: an electrochemical overview. BioMed Research International, 2013, Article ID 251754, 11 pages. doi: org/10.1155/2013/251754 Go to original source...
    69. Tsou M.F., Hung C.F., Lu H.F., Wu L.T., Chang S.H., Chang H.L., Chen G.W., Chung J.G. (2000): Effects of caffeic acid, chlorogenic acid and ferulic acid on growth and arylamine N-acetyltransferase activity in Shigella sonnei (group D): Microbios, 101: 37-46.
    70. Verma B., Hucl P., Chibbar R.N. (2009): Phenolic acid composition and antioxidant capacity and alkali hydrolysed wheat bran fractions. Food Chemistry, 116: 947-954. Go to original source...
    71. Wang L., Yao Y., He Z., Wang D., Liu A., Zhang Y. (2013): Determination of phenolic acid concentrations in wheat flours produced at different extraction rates. Journal of Cereal Science, 57: 67-72. Go to original source...
    72. Weidner S., Amarowicz R., Karamaæ M., D±browski G. (1999): Phenolic acids in caryopses of two cultivars of wheat, rye and triticale that display different resistance to pre-harvest sprouting. European Food Research and Technology, 210: 109-113. Go to original source...
    73. Weidner S., Amarowicz R., Karamac M., Frtczeka E. (2000): Changes in endogenous phenolic acids during development of Secale cereale caryopses and after dehydration treatment of unripe rye grains. Plant Physiology and Biochemistry, 38: 595-602. Go to original source...
    74. Yang F., Basu T.K., Ooraikul B. (2001): Studies on germination: conditions and antioxidant contents of wheat grain. International Journal of Food Science and Nutrition, 52: 319-330. Go to original source... Go to PubMed...
    75. Young I.S., Woodside J.V. (2001): Antioxidants in health and disease. Journal of Clinical Pathology, 54: 176-186. Go to original source... Go to PubMed...
    76. Zhang Z.E., Yao S.D., Lin W.Z., Wang W.F., Jin Y.Z., Lin N.Y. (1998): Mechanism of reaction of nitrogen dioxide radical with hydroxycinnamic acid derivatives: a pulse radiolysis study. Free Radical Research, 29: 13-16. Go to original source... Go to PubMed...
    77. Zhao Z., Egashira Y., Sanada H. (2005): Phenolic antioxidants richly contained in corn bran are slightly bioavailable in rats. Journal of Agricultural and Food Chemistry, 53: 5030-5035. Go to original source... Go to PubMed...
    78. Zhao Z., Moghadasian M.H. (2008): Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: a review. Food Chemistry, 109: 691-702. Go to original source... Go to PubMed...

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