Vet Med - Czech, 2012, 57(1):1-35 | DOI: 10.17221/4969-VETMED

Sulfonamides in the environment: a review and a case report

K. Hruska, M. Franek
Veterinary Research Institute, Brno, Czech Republic

Sulfonamides are widely used in treatment of animals and humans but pose a risk as environmental pollutants. An analysis of 1588 publications focused on sulfonamides is presented here. The review deals with environmental pollution with sulfonamides, described in papers indexed in the database Web of Science from 1938 to 2011. More in depth details are presented regarding publication activity during the last ten years in which 1255 papers have been published by authors from 1100 institutions. Papers, published during the last three years and mainly in 2011, are listed in comprehensive tables, sorted according to five criteria: reviews, contaminated niches, risk of contamination, sulfonamide transformation and methods of analysis. Key words and shortened abstracts direct the reader to the topics of interest. Hyperlinks to full papers, published in open access journals, are another aid in knowledge dissemination. This design of the review article allows easy navigation through vast amounts of information. Finally, a case report illustrates experiences from the author's laboratory with sulfamethazine determination in pig slurry by ELISA. The reported results highlight the need for updating the legal directives for environmental protection.

Keywords: sulfonamides; sulfamethazine; sulfamethoxazole; environmental protection; bacterial resistance; pig slurry; novel review design

Published: January 31, 2012  Show citation

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Hruska K, Franek M. Sulfonamides in the environment: a review and a case report. Vet Med-Czech. 2012;57(1):1-35. doi: 10.17221/4969-VETMED.
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    References

    1. Almeida SAA, Amorim LR, Heitor AH, Montenegro MCBS, Barbosa J, Sa LC, Sales MGF (2011a): Rapid automated method for on-site determination of sulfadiazine in fish farming: a stainless steel veterinary syringe coated with a selective membrane of PVC serving as a potentiometric detector in a flow-injectionanalysis system. Analytical and Bioanalytical Chemistry 401, 3355-3365. Go to original source... Go to PubMed...
    2. Almeida SAA, Heitor AM, Montenegro MCBS, Sales MGF (2011b): Sulfadiazine-selective determination in aquaculture environment: Selective potentiometric transduction by neutral or charged ionophores. Talanta 85, 1508-1516. Go to original source... Go to PubMed...
    3. Baran W, Adamek E, Ziemianska J, Sobczak A (2011): Effects of the presence of sulfonamides in the environment and their influence on human health. Journal of Hazardous Materials 196, 1-15. Go to original source... Go to PubMed...
    4. Bialk-Bielinska A, Siedlewicz G, Stepnowski P, Pazdro K, Fabianska A, Kumirska J (2011): A very fast and simple method for the determination of sulfonamide residues in seawaters. Analytical Methods 3, 1371-1378. Go to original source...
    5. Blackwell PA, Kay P, Ashauer R, Boxall ABA (2009): Effects of agricultural conditions on the leaching behaviour of veterinary antibiotics in soils. Chemosphere 75, 13-19. Go to original source... Go to PubMed...
    6. Borras S, Companyo R, Guiteras J (2011): Analysis of sulfonamides in animal feeds by liquid chromatography with fluorescence detection. Journal of Agricultural and Food Chemistry 59, 5240-5247. Go to original source... Go to PubMed...
    7. Brenner CGB, Mallmann CA, Arsand DR, Mayer FM, Martins AF (2011): Determination of sulfamethoxazole and trimethoprim and their metabolites in hospital effluent. Clean-Soil Air Water 39, 28-34. Go to original source...
    8. Buchberger WW (2011): Current approaches to trace analysis of pharmaceuticals and personal care products in the environment. Journal of Chromatography A 1218, 603-618. Go to original source... Go to PubMed...
    9. Byrne-Bailey KG, Gaze WH, Kay P, Boxall ABA, Hawkey PM, Wellington EMH (2009): Prevalence of sulfonamide resistance genes in bacterial isolates from manured agricultural soils and pig slurry in the United Kingdom. Antimicrobial Agents and Chemotherapy 53, 696-702. Go to original source... Go to PubMed...
    10. Chen H, Gao B, Li H, Ma LQ (2011): Effects of pH and ionic strength on sulfamethoxazole and ciprofloxacin transport in saturated porous media. Journal of Contaminant Hydrology 126, 29-36. Go to original source... Go to PubMed...
    11. Chen LG, Zeng QL, Wang H, Su R, Xu Y, Zhang XP, Yu AM, Zhang HQ, Ding L (2009): On-line coupling of dynamic microwave-assisted extraction to solid-phase extraction for the determination of sulfonamide antibiotics in soil. Analytica Chimica Acta 648, 200-206. Go to original source... Go to PubMed...
    12. Ding YJ, Zhang WH, Gu C, Xagoraraki I, Li H (2011): Determination of pharmaceuticals in biosolids using accelerated solvent extraction and liquid chromatography/tandem mass spectrometry. Journal of Chromatography A 1218, 10-16. Go to original source... Go to PubMed...
    13. Dirany A, Aaron SE, Oturan N, Sires I, Oturan MA, Aaron JJ (2011): Study of the toxicity of sulfamethoxazole and its degradation products in water by a bioluminescence method during application of the electro-Fenton treatment. Analytical and Bioanalytical Chemistry 400, 353-360. Go to original source... Go to PubMed...
    14. Fan ZS, Casey FXM, Hakk H, Larsen GL, Khan E (2011): Sorption, fate, and mobility of sulfonamides in soils. Water Air and Soil Pollution 218, 49-61. Go to original source...
    15. Forrest F, Lorenz K, Thompson T, Keenliside J, Kendall J, Charest J (2011): A scoping study of livestock antimicrobials in agricultural streams of Alberta. Canadian Water Resources Journal 36, 1-16. Go to original source...
    16. Franek M, Hruska K (2005): Antibody based methods for environmental and food analysis: a review. Veterinarni Medicina 50, 1-10. Go to original source...
    17. Franek M, Kolar V, Deng AP, Crooks S (1999): Determination of sulphadimindine (sulfamethazine) residues in milk, plasma, urine and edible tissues by sensitive ELISA. Food and Agricultural Immunology 11, 339-349. Go to original source...
    18. Garcia-Campana AM, Gamiz-Gracia L, Lara FJ, Iruela MD, Cruces-Blanco C (2009): Applications of capillary electrophoresis to the determination of antibiotics in food and environmental samples. Analytical and Bioanalytical Chemistry 395, 967-986. Go to original source... Go to PubMed...
    19. Garcia-Galan MJ, Diaz-Cruz MS, Barcelo D (2009): Combining chemical analysis and ecotoxicity to determine environmental exposure and to assess risk from sulfonamides. Trac-Trends in Analytical Chemistry 28, 804-819. Go to original source...
    20. Garcia-Galan MJ, Diaz-Cruz MS, Barcelo D (2010a): Determination of 19 sulfonamides in environmental water samples by automated on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry (SPE-LC-MS/MS). Talanta 81, 355-366. Go to original source... Go to PubMed...
    21. Garcia-Galan MJ, Garrido T, Fraile J, Ginebreda A, DiazCruz MS, Barcelo D (2010b): Simultaneous occurrence of nitrates and sulfonamide antibiotics in two ground water bodies of Catalonia (Spain). Journal of Hydrology 383, 93-101. Go to original source...
    22. Garcia-Galan MJ, Rodriguez-Rodriguez CE, Vicent T, Caminal G, Diaz-Cruz MS, Barcelo D (2011a): Biodegradation of sulfamethazine by Trametes versicolor: Removal from sewage sludge and identification of intermediate products by UPLC-QqTOF-MS. Science of the Total Environment 409, 5505-5512. Go to original source... Go to PubMed...
    23. Garcia-Galan MJ, Diaz-Cruz MS, Barcelo D (2011b): Occurrence of sulfonamide residues along the Ebro River Basin removal in wastewater treatment plants and environmental impact assessment. Environment International 37, 462-473. Go to original source... Go to PubMed...
    24. Garcia-Galan MJ, Garrido T, Fraile J, Ginebreda A, Diaz-Cruz MS, Barcelo D (2011c): Application of fully automated online solid phase extraction-liquid chromatography-electrospray-tandem mass spectrometry for the determination of sulfonamides and their acetylated metabolites in groundwater. Analytical and Bioanalytical Chemistry 399, 795-806. Go to original source... Go to PubMed...
    25. Graves AK, Liwimbi L, Israel DW, van Heugten E, Robinson B, Cahoon CW, Lubbers JF (2011): Distribution of ten antibiotic resistance genes in E. coli isolates from swine manure, lagoon effluent and soil collected from a lagoon waste application field. Folia Microbiologica 56, 131-137. Go to original source... Go to PubMed...
    26. Guo JB, Ostermann A, Siemens J, Dong RJ, Clemens J (2012): Short term effects of copper, sulfadiazine and difloxacin on the anaerobic digestion of pig manure at low organic loading rates. Waste Management 32, 131-136. Go to original source... Go to PubMed...
    27. Guo YC, Ngom B, Le T, Jin X, Wang LP, Shi DS, Wang XL, Bi DG (2010): Utilizing three monoclonal antibodies in the development of an immunochromatographic assay for simultaneous detection of sulfamethazine, sulfadiazine, and sulfaquinoxaline residues in egg and chicken muscle. Analytical Chemistry 82, 7550-7555. Go to original source... Go to PubMed...
    28. Hammesfahr U, Bierl R, Thiele-Bruhn S (2011): Combined effects of the antibiotic sulfadiazine and liquid manure on the soil microbial-community structure and functions. Journal of Plant Nutrition and Soil Science 174, 614-623. Go to original source...
    29. Heuer H, Kopmann C, Binh CTT, Top EM, Smalla K (2009): Spreading antibiotic resistance through spread manure: characteristics of a novel plasmid type with low %G plus C content. Environmental Microbiology 11, 937-949. Go to original source... Go to PubMed...
    30. Heuer H, Solehati Q, Zimmerling U, Kleineidam K, Schloter M, Muller T, Focks A, Thiele-Bruhn S, Smalla K (2011): Accumulation of sulfonamide resistance genes in arable soils due to repeated application of manure containing sulfadiazine. Applied and Environmental Microbiology 77, 2527-2530. Go to original source... Go to PubMed...
    31. Hillis DG, Fletcher J, Solomon KR, Sibley PK (2011): Effects of ten antibiotics on seed germination and root elongation in three plant species. Archives of Environmental Contamination and Toxicology 60, 220- 232. Go to original source... Go to PubMed...
    32. Holzel CS, Harms KS, Kuchenhoff H, Kunz A, Muller C, Meyer K, Schwaiger K, Bauer J (2010): Phenotypic and genotypic bacterial antimicrobial resistance in liquid pig manure is variously associated with contents of tetracyclines and sulfonamides. Journal of Applied Microbiology 108, 1642-1656. Go to original source... Go to PubMed...
    33. Hu XG, Luo Y, Zhou QX (2010): Simultaneous analysis of selected typical antibiotics in manure by microwave-assisted extraction and LC-MS (n). Chromatographia 71, 217-223. Go to original source...
    34. Hunter WJ, Shaner DL (2011): Studies on removing sulfachloropyridazine from groundwater with microbial bioreactors. Current Microbiology 62, 1560-1564. Go to original source... Go to PubMed...
    35. Jia A, Hu JY, Wu XQ, Peng H, Wu SM, Dong ZM (2011): Occurrence and source apportionment of sulfonamides and their metabolites in liaodong bay and the adjacent Liao River Basin, North China. Environmental Toxicology and Chemistry 30, 1252-1260. Go to original source... Go to PubMed...
    36. Jiang L, Hu XL, Yin DQ, Zhang HC, Yu ZY (2011): Occurrence, distribution and seasonal variation of antibiotics in the Huangpu River, Shanghai, China. Chemosphere 82, 822-828. Go to original source... Go to PubMed...
    37. Jornet D, Gonzalez-Martinez MA, Puchades R, Maquieira A (2010): Antibiotic immunosensing: Determination of sulfathiazole in water and honey. Talanta 81, 1585-1592. Go to original source... Go to PubMed...
    38. Jury KL, Khan SJ, Vancov T, Stuetz RM, Ashbolt NJ (2011): Are sewage treatment plants promoting antibiotic resistance? Critical Reviews in Environmental Science and Technology 41, 243-270. Go to original source...
    39. Karczmarczyk M, Walsh C, Slowey R, Leonard N, Fanning S (2011): Molecular characterization of multidrug-resistant Escherichia coli isolates from Irish cattle farms. Applied and Environmental Microbiology 77, 7121-7127. Go to original source... Go to PubMed...
    40. Kim KR, Owens G, Ok YS, Park WK, Lee DB, Kwon SI (2012): Decline in extractable antibiotics in manurebased composts during composting. Waste Management 32, 110-116. Go to original source... Go to PubMed...
    41. Kreuzig R (2010): The reference manure concept for transformation tests of veterinary medicines and biocides in liquid manure. Clean-Soil Air Water 38, 697-705. Go to original source...
    42. Kurwadkar ST, Adams CD, Meyer MT, Kolpin DW (2011): Comparative mobility of sulfonamides and bromide tracer in three soils. Journal of Environmental Management 92, 1874-1881. Go to original source... Go to PubMed...
    43. Kwon JW (2011): Mobility of veterinary drugs in soil with application of manure compost. Bulletin of Environmental Contamination and Toxicology 87, 40-44. Go to original source... Go to PubMed...
    44. Kwon SI, Owens G, Ok YS, Lee DB, Jeon WT, Kim JG, Kim KR (2011): Applicability of the Charm II system for monitoring antibiotic residues in manure-based composts. Waste Management 31, 39-44. Go to original source... Go to PubMed...
    45. Lai HT, Wang TS, Chou CC (2011): Implication of light sources and microbial activities on degradation of sulfonamides in water and sediment from a marine shrimp pond. Bioresource Technology 102, 5017-5023. Go to original source... Go to PubMed...
    46. Larcher S, Yargeau V (2011): Biodegradation of sulfamethoxazole by individual and mixed bacteria. Applied Microbiology and Biotechnology 91, 211-218. Go to original source... Go to PubMed...
    47. Le-Minh N, Khan SJ, Drewes JE, Stuetz RM (2010): Fate of antibiotics during municipal water recycling treatment processes. Water Research 44, 4295-4323. Go to original source... Go to PubMed...
    48. Li H, Kijak PJ (2011): Development of a quantitative multiclass/multiresidue method for 21 veterinary drugs in shrimp. Journal of AOAC International 94, 394-406. Go to original source... Go to PubMed...
    49. Li WJ, Peng XJ, Wang HY, Liang Z, Luan ZK (2011a): UV irradiation for removal of veterinary antibiotics. Fresenius Environmental Bulletin 20, 93-98.
    50. Li YW, Wu XL, Mo CH, Tai YP, Huang XP, Xiang L (2011b): Investigation of sulfonamide, tetracycline, and quinolone antibiotics in vegetable farmland soil in the Pearl River Delta area, Southern China. Journal of Agricultural and Food Chemistry 59, 7268-7276. Go to original source... Go to PubMed...
    51. Liu F, Ying GG, Tao R, Jian-Liang Z, Yang JF, Zhao LF (2009): Effects of six selected antibiotics on plant growth and soil microbial and enzymatic activities. Environmental Pollution 157, 1636-1642. Go to original source... Go to PubMed...
    52. Luo Y, Xu L, Rysz M, Wang YQ, Zhang H, Alvarez PJJ (2011): Occurrence and transport of tetracycline, sulfonamide, quinolone, and macrolide antibiotics in the Haihe River Basin, China. Environmental Science and Technology 45, 1827-1833. Go to original source... Go to PubMed...
    53. Ma YJ, Wilson CA, Novak JT, Riffat R, Aynur S, Murthy S, Prudens A (2011): Effect of various sludge digestion conditions on sulfonamide, macrolide, and tetracycline resistance genes and class I integrons. Environmental Science and Technology 45, 7855-7861. Go to original source... Go to PubMed...
    54. Martins AF, Mallmann CA, Arsand DR, Mayer FM, Brenner CGB (2011): Occurrence of the antimicrobials sulfamethoxazole and trimethoprim in hospital effluent and study of their degradation products after electrocoagulation. Clean-Soil Air Water 39, 21-27. Go to original source...
    55. Meyer B, Pailler JY, Guignard C, Hoffmann L, Krein A (2011): Concentrations of dissolved herbicides and pharmaceuticals in a small river in Luxembourg. Environmental Monitoring and Assessment 180, 127-146. Go to original source... Go to PubMed...
    56. Mohatt JL, Hu LH, Finneran KT, Strathmann TJ (2011): Microbially mediated abiotic transformation of the antimicrobial agent sulfamethoxazole under iron-reducing soil conditions. Environmental Science and Technology 45, 4793-4801. Go to original source... Go to PubMed...
    57. Motoyama M, Nakagawa S, Tanoue R, Sato Y, Nomiyama K, Shinohara R (2011): Residues of pharmaceutical products in recycled organic manure produced from sewage sludge and solid waste from livestock and relationship to their fermentation level. Chemosphere 84, 432-438. Go to original source... Go to PubMed...
    58. Murata A, Takada H, Mutoh K, Hosoda H, Harada A, Nakada N (2011): Nationwide monitoring of selected antibiotics: Distribution and sources of sulfonamides, trimethoprim, and macrolides in Japanese rivers. Science of the Total Environment 409, 5305-5312. Go to original source... Go to PubMed...
    59. Na GS, Gu J, Ge LK, Zhang P, Wang Z, Liu CY, Zhang L (2011): Detection of 36 antibiotics in coastal waters using high performance liquid chromatography-tandem mass spectrometry. Chinese Journal of Oceanology and Limnology 29, 1093-1102. Go to original source...
    60. Namera A, Nakamoto A, Saito T, Miyazaki S (2011): Monolith as a new sample preparation material: Recent devices and applications. Journal of Separation Science 34, 901-924. Go to original source... Go to PubMed...
    61. Nesterenko IS, Nokel MA, Eremin SA (2009): Immunochemical methods for the detection of sulfanylamide drugs. Journal of Analytical Chemistry 64, 435-444. Go to original source...
    62. Ozkorucuklu SP, Ozcan L, Sahin Y, Alsancak G (2011): Electroanalytical determination of some sulfonamides on overoxidized polypyrrole electrodes. Australian Journal of Chemistry 64, 965-972. Go to original source...
    63. Pan X, Qiang ZM, Ben WW, Chen MX (2011a): Residual veterinary antibiotics in swine manure from concentrated animal feeding operations in Shandong Province, China. Chemosphere 84, 695-700. Go to original source... Go to PubMed...
    64. Pan X, Qiang ZM, Ben WW, Chen MX (2011b): Simultaneous determination of three classes of antibiotics in the suspended solids of swine wastewater by ultrasonic extraction, solid-phase extraction and liquid chromatography-mass spectrometry. Journal of Environmental Sciences 23, 1729-1737. Go to original source... Go to PubMed...
    65. Pastor-Navarro N, Brun EM, Gallego-Iglesias E, Maquieira A, Puchades R (2009): Development of immunoassays to determinate sulfamethoxazole residues in wastewaters. Journal of Environmental Monitoring 11, 1094-1100. Go to original source... Go to PubMed...
    66. Payan MR, Lopez MAB, Fernandez-Torres R, Navarro MV, Mochon MC (2011): Hollow fiber-based liquid phase microextraction (HF-LPME) for a highly sensitive HPLC determination of sulfonamides and their main metabolites. Journal of Chromatography B 879, 197-204. Go to original source... Go to PubMed...
    67. Pedrouzo M, Borrull F, Pocurull E, Marce RM (2011): Presence of pharmaceuticals and hormones in waters from sewage treatment plants. Water Air and Soil Pollution 217, 267-281. Go to original source...
    68. Peng XZ, Zhang K, Tang CM, Huang QX, Yu YY, Cui JL (2011): Distribution pattern, behavior, and fate of antibacterials in urban aquatic environments in South China. Journal of Environmental Monitoring 13, 446-454. Go to original source... Go to PubMed...
    69. Persoons D, Haesebrouck F, Smet A, Herman L, Heyndrickx M, Martel A, Catry B, Berge AC, Butaye P, Dewulf J (2011): Risk factors for ceftiofur resistance in Escherichia coli from Belgian broilers. Epidemiology and Infection 139, 765-771. Go to original source... Go to PubMed...
    70. Pinero MY, Bauza R, Arce L (2011): Thirty years of capillary electrophoresis in food analysis laboratories: Potential applications. Electrophoresis 32, 1379-1393. Go to original source... Go to PubMed...
    71. Raich-Montiu J, Beltran JL, Prat MD, Granados M (2010): Studies on the extraction of sulfonamides from agricultural soils. Analytical and Bioanalytical Chemistry 397, 807-814. Go to original source... Go to PubMed...
    72. Sahar E, Ernst M, Godehardt M, Hein A, Herr J, Kazner C, Melin T, Cikurel H, Aharoni A, Messalem R, Brenner A, Jekel M (2011): Comparison of two treatments for the removal of selected organic micropollutants and bulk organic matter: conventional activated sludge followed by ultrafiltration versus membrane bioreactor. Water Science and Technology 63, 733-740. Go to original source... Go to PubMed...
    73. Samanidou VF, Karageorgou EG (2011): An overview of the use of monoliths in sample preparation and analysis of milk. Journal of Separation Science 34, 2013-2025. Go to original source... Go to PubMed...
    74. Sarmah AK, Meyer MT, Boxall ABA (2006): A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment. Chemosphere 65, 725-759. Go to original source... Go to PubMed...
    75. Seifrtova M, Novakova L, Lino C, Pena A, Solich P (2009): An overview of analytical methodologies for the determination of antibiotics in environmental waters. Analytica Chimica Acta 649, 158-179. Go to original source... Go to PubMed...
    76. Sharma VK (2010): Oxidation of nitrogen-containing pollutants by novel ferrate (VI) technology: A review. Journal of Environmental Science and Health Part A 45, 645-667. Go to original source... Go to PubMed...
    77. Shelver WL, Hakk H, Larsen GL, DeSutter TM, Casey FXM (2010): Development of an ultra-high-pressure liquid chromatography-tandem mass spectrometry multiresidue sulfonamide method and its application to water, manure slurry, and soils from swine rearing facilities. Journal of Chromatography A 1217, 1273-1282. Go to original source... Go to PubMed...
    78. Sukul P, Spiteller M (2006): Sulfonamides in the environment as veterinary drugs. Reviews of Environmental Contamination and Toxicology, 187, 67-101. Go to original source... Go to PubMed...
    79. Tamtam F, van Oort F, Le Bot B, Dinh T, Mompelat S, Chevreuil M, Lamy I, Thiry M (2011): Assessing the fate of antibiotic contaminants in metal contaminated soils four years after cessation of long-term waste water irrigation. Science of the Total Environment 409, 540-547. Go to original source... Go to PubMed...
    80. Tolika EP, Samanidou VF, Papadoyannis IN (2010): An overview of chromatographic analysis of sulfonamides in pharmaceutical preparations and biological fluids. Current Pharmaceutical Analysis 6, 198-212. Go to original source...
    81. Tong L, Li P, Wang YX, Zhu KZ (2009): Analysis of veterinary antibiotic residues in swine wastewater and environmental water samples using optimized SPE-LC/MS/ MS. Chemosphere 74, 1090-1097. Go to original source... Go to PubMed...
    82. Tso J, Dutta S, Inamdar S, Aga DS (2011): Simultaneous analysis of free and conjugated estrogens, sulfonamides, and tetracyclines in runoff water and soils using solidphase extraction and liquid chromatography-tandem mass spectrometry. Journal of Agricultural and Food Chemistry 59, 2213-2222. Go to original source... Go to PubMed...
    83. Watanabe N, Bergamaschi BA, Loftin KA, Meyer MT, Harter T (2010): Use and environmental occurrence of antibiotics in freestall dairy farms with manured forage fields. Environmental Science and Technology 44, 6591- 6600. Go to original source... Go to PubMed...
    84. Wei RC, Ge F, Huang SY, Chen M, Wang R (2011): Occurrence of veterinary antibiotics in animal wastewater and surface water around farms in Jiangsu Province, China. Chemosphere 82, 1408-1414. Go to original source... Go to PubMed...
    85. Wu CQ, Chen DY, Zhou AJ, Deng HM, Liu YH (2011): Determination of sulfonamides in water sample using ionic liquid-based single drop microextraction coupled with high performance liquid chromatography. Chinese Journal of Analytical Chemistry 39, 17-21. Go to original source...
    86. Xie XG, Wang Y, Han JA, Yan YS (2011): Extraction mechanism of sulfamethoxazole in water samples using aqueous two-phase systems of poly (propylene glycol) and salt. Analytica Chimica Acta 687, 61-66. Go to original source... Go to PubMed...
    87. Zarfl C, Klasmeier J, Matthies M (2009): A conceptual model describing the fate of sulfadiazine and its metabolites observed in manure-amended soils. Chemosphere 77, 720-726. Go to original source... Go to PubMed...
    88. Zhang T, Li B (2011): Occurrence, transformation, and fate of antibiotics in municipal wastewater treatment plants. Critical Reviews in Environmental Science and Technology 41, 951-998. Go to original source...
    89. Zhang Z, Liu JF, Shao B, Jiang GB (2010): Time-resolved fluoroimmunoassay as an advantageous approach for highly efficient determination of sulfonamides in environmental waters. Environmental Science and Technology 44, 1030-1035. Go to original source... Go to PubMed...
    90. Zhao L, Dong YH, Wang H (2010): Residues of veterinary antibiotics in manures from feedlot livestock in eight provinces of China. Science of the Total Environment 408, 1069-1075. Go to original source... Go to PubMed...

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