Vet Med - Czech, 2012, 57(5):233-238 | DOI: 10.17221/5953-VETMED

Reference data of clinical chemistry, haematology and blood coagulation parameters in juvenile cynomolgus monkeys (Macaca fascicularis)

H. Wang1,2, Y.Y. Niu1,2, W. Si1,2, Y.J. Li2, Y. Yan1,2
1 Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China
2 Kunming Biomed International and Yunnan Key Laboratory of Primate Biomedical Research, Kunming, China

Juvenile cynomolgus monkeys are valuable models for studying human diseases. Reference data of clinical chemistry, haematology and blood coagulation parameters of juvenile cynomolgus monkeys are very important for clinical diagnosis and conducting research. In this study, 72 blood samples (obtained from 35 males and 37 females) and 20 blood samples (obtained from 10 males and 10 females) were used to determine normal data of clinical serum chemistry, haematological profiles and normal blood coagulation parameters in juvenile cynomolgus monkeys. Seventeen markers of clinical serum chemistry, twenty-nine markers of haematology and two parameters of blood coagulation were analysed. These data may provide valuable information for veterinarians and investigators using juvenile cynomolgus monkeys in research on disease treatment and in experimental studies.

Keywords: serum chemical parameters; complete blood count; prothrombin time; activated partial thromboplastin time; juvenile Macaca fascicularis

Published: May 31, 2012  Show citation

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Wang H, Niu YY, Si W, Li YJ, Yan Y. Reference data of clinical chemistry, haematology and blood coagulation parameters in juvenile cynomolgus monkeys (Macaca fascicularis). Vet Med-Czech. 2012;57(5):233-238. doi: 10.17221/5953-VETMED.
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References

  1. Andrade MCR, Ribeiro CT, Silva VF, Molinaro EM, Goncalves MAB, Marques MAP, Cabello PH, Leite JPG (2004): Biologic data of Macaca mulatta, Macaca fascicularis, and Saimiri sciureus used for research at the Fiocruz primate center. Mem Inst Oswaldo Cruz, Rio de Janeiro 99, 581-589. Go to original source...
  2. Chen YN, Qin SF, Ding Y, Wei LL, Zhang J, Li HX, Bu H, Lu YR, Cheng JQ (2009): Reference values of clinical chemistry and hematology parameters in rhesus monkeys(Macaca mulatta). Xenotransplantation 16, 496-501. Go to original source... Go to PubMed...
  3. Ives M, Dack GM (1956): 'Alarm reaction' and normal blood pictures in Macaca mulatta. Laboratory and Clinical Medicine 47, 723-729.
  4. Kaplan JN (1977): Breeding and rearing squirrel monkeys (Saimiri sciureus) in captivity. Laboratory Animal Science 27, 557-567.
  5. Matsuzawa T, Nagai Y (1994): Comparative haematological and plasma chemistry values in purpose-bred squirrel, cynomolgus and rhesus monkeys. Comparative Haematology International 4, 43-48. Go to original source...
  6. Melville GSJ, Whitcomb WH, Martinez RS (1967): Hematology of the Macaca mulatta monkey. Laboratory Animal Care 17, 180-198. Go to PubMed...
  7. Schuurman HJ, Smith HT (2005): Reference values for clinical chemistry and clinical hematology parameters in cynomolgus monkeys. Xenotransplantation 12, 72-75. Go to original source... Go to PubMed...
  8. Schuurman HJ, Smith HT, Cozzi E (2004): Reference values for clinical chemistry and clinical hematology parameters in baboons. Xenotransplantation 11, 511-516. Go to original source... Go to PubMed...

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