Plant Protect. Sci., 2015, 51(4):163-169 | DOI: 10.17221/83/2015-PPS

Recent developments and challenges in chemical disease control - a reviewReview

Andy LEADBEATER
Syngenta Crop Protection AG, Basel, Switzerland

The use of chemical fungicides to control plant diseases is an integral component of crop management. Although fungicides have been used to good effect in agriculture since the 1940s, the introduction of new fungicides is an essential element to provide sustained control of major crop diseases. The need for new and innovative fungicides is driven, among other factors, by resistance management, regulatory hurdles, and increasing customer expectations. New fungicides can be discovered either within established mode of action groups, ideally with low resistance risk (robust modes of action), or in areas with completely novel modes of action. Compounds having a novel mode of action are of course of special interest, since they play a key role in resistance management strategies, but equally important are new fungicides with enhanced characteristics such as systemicity, curativity, and longevity of disease control. With the background of increasing registration hurdles, increasing costs, and increasing market needs, the current market position of major crop protection fungicides needs to be reviewed, along with the consideration of current and future market needs. An analysis of the situation regarding new fungicidal compounds in late development or recently introduced to the market suggests that considerable innovation continues to be delivered in the chemical fungicide area. New modes of action are quite rare in some segments (major new fungicides are mainly SDHIs), but seem to be more frequently discovered for the control of oomycetes. Potential reasons for this are discussed.

Keywords: fungicides; research and development; fungicide resistance; strobilurins; triazoles; carboximides

Published: December 31, 2015  Show citation

ACS AIP APA ASA Harvard Chicago IEEE ISO690 MLA NLM Turabian Vancouver
LEADBEATER A. Recent developments and challenges in chemical disease control - a review. Plant Protect. Sci.. 2015;51(4):163-169. doi: 10.17221/83/2015-PPS.
Download citation

References

  1. FRAC: Available at www.frac.info
  2. Glättli A., Grotel T., Stammler G. (2011): SDH-inhibitors: History, biological performance and molecular mode of action. In: Dehne H.-W., Deising H.B., Gisi U., Kuck K.H., Russell P.E., Lyr H. (eds): Modern Fungicides and Antifungal Compounds. VI. Braunschweig, DPG-Verlag: 159-170.
  3. Leadbeater A.J. (2011): The impact of the new European regulations on the management of crop diseases. In: Dehne H.-W., Deising H.B., Gisi U., Kuck K.H., Russell P.E., Lyr H. (eds): Modern Fungicides and Antifungal Compounds VI. Braunschweig, DPG-Verlag: 1-10.
  4. Leadbeater A., Gisi U. (2010): The challenges of chemical control of plant diseases. Chapter 1. In: Gisi U., Chet I., Gullino M.L. (eds): Recent Developments in Management of Plant Diseases, Plant Pathology in the 21th Century. Vol. 1. Dordrecht, Springer Science + Business Media: 3-17. Go to original source...
  5. McDougall P. (2010): The Cost of New Agrochemical Product Discovery, Development and Registration in 1995, 2000 and 2005-8. Available at http://www.croplife.org/view_document.aspx?docId=2478
  6. McDougall P. (2014): Trends in Industry Research and Development. AgriFutura No 174, April 2014. Available at www.phillipsmcdougall.com
  7. Russell P.E. (2005): A century of fungicide evolution. Journal of Agricultural Science, 143: 11-25. Go to original source...
  8. Sierotzki H., Scalliet G. (2013). A review of current knowledge of resistance aspects for the next-generation succinate dehydrogenase inhibitor fungicides. Phytopathology, 103: 880-887. Go to original source... Go to PubMed...

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.