Year 2016 / Volume 108 / Number 4
Original
Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain

181-189

DOI: 10.17235/reed.2016.4094/2015

Julián Rodríguez Almagro, Antonio Hernández Martínez, Alfredo José Lucendo, Francesc Casellas, Maria Carmen Solano Ruiz, José Siles González,

Abstract
Background: Celiac disease (CD) has a negative impact on the health-related quality of life (HRQL) of affected patients. Although HRQL and its determinants have been examined in Spanish CD patients specifically recruited in hospital settings, these aspects of CD have not been assessed among the general Spanish population. Methods: An observational, transversal study of a non-randomized, representative sample of adult celiac patients throughout all of Spain's Autonomous Regions. Subjects were recruited through celiac patient associations. A Spanish version of the self-administered Celiac Disease-Quality of Life (CD-QOL) questionnaire was used. Determinant factors of HRQL were assessed with the aid of multivariate analysis to control for confounding factors. Results: We analyzed the responses provided by 1,230 patients, 1,092 (89.2%) of whom were women. The overall mean value for the CD-QOL index was 56.3 ± 18.27 points. The dimension that obtained the most points was dysphoria, with 81.3 ± 19.56 points, followed by limitations with 52.3 ± 23.43 points; health problems, with 51.6 ± 26.08 points, and inadequate treatment, with 36.1 ± 21.18 points. Patient age and sex, along with time to diagnosis, and length of time on a gluten-free diet were all independent determinant factors of certain dimensions of HRQL: women aged 31 to 40 expressed poorer HRQL while time to diagnosis and length of time on a gluten-free diet were determinant factors for better HRQL scores. Conclusions: The HRQL of adult Spanish celiac subjects is moderate, improving with the length of time patients remain on a gluten-free diet.
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Rodríguez Almagro J, Hernández Martínez A, Lucendo A, Casellas F, Solano Ruiz M, Siles González J, et all. Health-related quality of life and determinant factors in celiac disease. A population-based analysis of adult patients in Spain. 4094/2015


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Publication history

Received: 09/11/2015

Accepted: 19/01/2016

Online First: 22/02/2016

Published: 01/04/2016

Article revision time: 69 days

Article Online First time: 105 days

Article editing time: 144 days


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