CORRELATION OF SERUM GFAP, PRDX1, NPT WITH SEVERITY AND PROGNOSIS OF CEREBRAL ISCHEMIC STROKE

Fanchuan Wang^{1, *}, Ziliang Yu², Kai Rong²

¹Department of Critical Care Medicine, Zibo Municipal Hospita, Zibo, PR China -  2 Department of Emergency, Zibo Municipal Hospita, Zibo, PR China - ²Department of Emergency, The People's Hospital of LinZi District, Zibo, PR China

Objective: To investigate the correlation of serum GFAP, PRDX1 and Npt with the severity and prognosis of cerebral ischemic stroke (CIS).

Methods: One hundred patients with cerebral ischemic stroke treated in our hospital from July 2018 to July 2019 were selected as the CIS group. According to the patients' NIHSS score, they were divided into a mild group (n = 36), moderate group (n = 34) and severe group (n = 30). According to the mRS score of patients, they were divided into a good prognosis group (n = 60) and a poor prognosis group (n = 40). Forty healthy people who underwent physical examination in our physical examination centre were selected as the control group. Enzyme-linked immunosorbent assay was used to detect the serum GFAP, PRDX1 and Npt levels of all subjects, and the serum GFAP, PRDX1 and Npt levels of all subjects were compared.

Results: The serum levels of GFAP, PRDX1 and Npt in patients with CIS group were significantly higher than those in the control group, and the differences were statistically significant (P<.01). Serum GFAP, PRDX1 and Npt levels were significantly higher in the severe group than in the moderate and mild groups. Serum GFAP, PRDX1 and Npt levels in patients with the syndrome group were significantly higher than those in the mild group (P<.01). The levels of serum GFAP, PRDX1 and Npt in patients with poor prognosis were significantly higher than those in the group with good prognosis, and the differences were statistically significant (P<.01). Pearson correlation analysis was used to determine that serum GFAP, PRDX1, and Npt levels were positively correlated with NIHSS scores (r were 0.156, 0.532 and 0.406, respectively, all P<.05). Serum GFAP, PRDX1 and Npt levels were positively correlated with mRS scores (r were 0.331, 0.423 and 0.512, all P<.05).

Conclusions: Serum GFAP, PRDX1 and Npt levels in patients with cerebral ischemic stroke increase with the severity of the patient's condition and the severity of the prognosis, which is positively correlated with the severity of the disease and the prognosis. They could be used as a test indicator to evaluate the severity of a patient's condition and prognosis.