Hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂; HAp) is one of inorganic components of bone and teeth, and has an osteoconductivity and execellent biocompatibility. Thus, the HAp has been used as biomaterials for bone graftings. Clinically-used HAp cements are set on the basis of the acid-base reaction of Ca₄O(PO₄)₂ and CaHPO₄. This mechanism accompany the changes of pH during hardening, leading to inflammation around tissues, together with slow setting time. We have succeeded to develop novel HAp cement, which is created by mixing the HAp powder modified with inositol phosphate (IP6) and water. The present IP6-HAp cement is set based on the chelate-bonding of IP6 without the acid-base reaction. The IP6 is not only biocompatible but also has able to chelate to some metal ions as strongly as EDTA. In the present study, we fabricated four kinds of IP6-HAp cements using commercially-available HAp powders with diferent morphology and specific surface area (SSA): HAp-100 (fine particle), HAp-200 (hexagonal shape), HAp-400 (plate shape), and s-HAp (spherical shape). Among the cement specimens examined, the IP6/HAp-100 cement derived from HAp-100 powder had maximum compressive strength of 10 MPa under following condition: Powder/Liquid (P/L) ratio=1/0.45[w/w]. The HAp-100 powder was composed of microcrystals with the highest SSA of 62.4 m²•g^-1 among the HAp powder used in the present work. On the other hand, the compressive strength of the IP6/HAp-200 cements showed the lowest value of 2 MPa under following condition: P/L ratio=1/0.35[w/w]. The HAp-200 powder of a starting material was composed of hexagonal-shaped crystals, and had the lowest SSA of 7.0 m²•g^-1. These results indicate that the compressive strength of novel IP6/HAp cements was affected by powder properties, especially, the morphology and SSA of starting HAp powders.