Nocturnal Oxyhemoglobin Desaturation and Prognosis in Chronic Obstructive Pulmonary Disease and Late Sequelae of Pulmonary Tuberculosis

Hiroshi KIMURA; Akira SUDA; Tetsuya SAKUMA; Koichiro TATSUMI; Yoshikazu KAWAKAMI; Takayuki KURIYAMA; W. Hida; E. Suzuki; K. Takahashi; Y. Fukuchi; T. Kawashiro; K. Nakata; M. Mohri; T. Kobayashi; S. Suetsugu; T. Miwa; K. Kuno; T. Sasaki; T. Hirose

doi:10.2169/internalmedicine.37.354

Hiroshi KIMURA, Akira SUDA, Tetsuya SAKUMA, Koichiro TATSUMI, Yoshikazu KAWAKAMI, Takayuki KURIYAMA, W. Hida, E. Suzuki, K. Takahashi, Y. Fukuchi, T. Kawashiro, K. Nakata, M. Mohri, T. Kobayashi, S. Suetsugu, T. Miwa, K. Kuno, T. Sasaki, T. Hirose

Author information

Hiroshi KIMURA
The Department of Chest Medicine, Chiba University School of Medicine, Chiba and the First Department of Medicine, Hokkaido University School of Medicine
Akira SUDA
The Department of Chest Medicine, Chiba University School of Medicine, Chiba and the First Department of Medicine, Hokkaido University School of Medicine
Tetsuya SAKUMA
The Department of Chest Medicine, Chiba University School of Medicine, Chiba and the First Department of Medicine, Hokkaido University School of Medicine
Koichiro TATSUMI
The Department of Chest Medicine, Chiba University School of Medicine, Chiba and the First Department of Medicine, Hokkaido University School of Medicine
Yoshikazu KAWAKAMI
The Department of Chest Medicine, Chiba University School of Medicine, Chiba and the First Department of Medicine, Hokkaido University School of Medicine
Takayuki KURIYAMA
The Department of Chest Medicine, Chiba University School of Medicine, Chiba and the First Department of Medicine, Hokkaido University School of Medicine
W. Hida
Tohoku University, First Department of Medicine
E. Suzuki
Niigata University, Second Department of Medicine
K. Takahashi
Yamagata University, Department of Laboratory Medicine
Y. Fukuchi
University of Tokyo, Department of Geriatrics
T. Kawashiro
Keio University, Department of Respiratory and Circulatory Medicine
K. Nakata
Toranomon Hospital
M. Mohri
National Tokyo Hospital
T. Kobayashi
Shinshu University, First Department of Medicine
S. Suetsugu
Fujita Health University Department of Internal Medicine
T. Miwa
Higashi-Nagoya Hospital
K. Kuno
Kyoto University, Chest Disease Research Institute
T. Sasaki
Tottori University, Third Department of Internal Medicine
T. Hirose
Minami-Fukuoka Hospital

Keywords: oxygen desaturation, sleep, respiratory failure, mortality

JOURNAL FREE ACCESS

1998 Volume 37 Issue 4 Pages 354-359

DOI https://doi.org/10.2169/internalmedicine.37.354

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Abstract

We prospectively examined the survival rate of 67 chronic obstructive pulmonary disease (COPD) and 74 late sequelae of pulmonary tuberculosis (TB seq) patients to clarify whether nocturnal oxyhemoglobin desaturation (NOD)could be one of the independent factors determining their mortality. The sleep monitoring of arterial oxygen saturation (SpO₂) and pulmonary function tests were assessed in all patients at the time of registration. Forty %of COPD and 24%of TB seq died as the direct result of deterioration of chronic respiratory failure during the 7-year observation period. Cox's proportional hazards analysis showed that NOD was an independent prognostic factor in both groups, and this was especially prominent when evaluated in terms of sleep lowest SpO₂ in COPD and 85% desaturation time in TB seq. No significant prognostic factor was observed among age, vital capacity percent predicted (%VC), forced expiratory volume in one second (FEV_1.0%)and partial pressure of carbon dioxide (PaCO₂). We conclude that the degree of NOD can affect mortality in COPD and TB seq.
(Internal Medicine 37: 354-359, 1998)

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