Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
A Mesenteric Liposarcoma with Production of Granulocyte Colony-Stimulating Factor
Akihiro NAKAMURAShigeki TANAKAHideaki TAKAYAMAMasashi SAKAMOTOHiroshi ISHIIMitsuo KUSANOYoshiko ONIZUKASyuichi OTAKeiji MITAMURA
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1998 Volume 37 Issue 10 Pages 884-890

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Abstract

A 77-year-old female was admitted to our hospital because of pyrexia and a right retroperitoneal mass. Leukocytosis and other inflammatory findings were noted. Bone-marrow aspiration revealed hypercellularity with no malignant cells. An additional mass was detected sonographically in the pelvis. The serum concentration of granulocyte colony-stimulating factor (G-CSF) was highly elevated (299 pg/ml). The tumors were removed at laparotomy, and the pelvic mass was found to arise from the ileocecal mesentery. Postoperatively, white blood cell count and serum G-CSF concentrations decreased to normal levels. The mesenteric tumor showed weakly positive immunostaining for human G-CSF, and Northern and polymerase chain reaction (PCR) analyses detected CSF and its mRNA in the mesenteric tumor.
(Internal Medicine 37: 884-890, 1998)

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© The Japanese Society of Internal Medicine
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