Internal Medicine
Online ISSN : 1349-7235
Print ISSN : 0918-2918
ISSN-L : 0918-2918
Asian Variant of CD5+ Intravascular Large B-cell Lymphoma with Splenic Infarction
Tatsuya TOKURA, Takuhei MURASE, Takayuki TORIYAMA, Yuji TOTANI, Masataka NEGITA, Kaoru AKAZA, Hiroaki OZAWA, Atsuko NAKAGAWA, Shigeo NAKAMURA
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Keywords: hemophagocytic syndrome, intravascular lymphoma, splenic infarction, Asian variant, splenectomy
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2003 Volume 42 Issue 1 Pages 105-109

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Abstract

A 57-year-old man was admitted with fever and epigastralgia, and presented with splenomegaly and pancytopenia. A CT scan revealed splenic infarctions. There were no lymphadenopathies, skin lesions, or neurological abnormalities. A splenectomy was performed. Bone marrow involvement with hemophagocytosis was noted. The diagnosis of Asian variant of intravascular diffuse large B-cell lymphoma was based on intravascular and sinusoidal distribution of large CD5+ B cells. The patient died of the disease 11 months after onset. To our knowledge, this is the first report of AIVL that presented with splenic infarction. This distinct lymphoma should be included in the differential diagnosis of splenic infarction.
(Internal Medicine 42: 105-109, 2003)

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