Cronkhite-Canada Syndrome Associated with Schizophrenia

Masaharu Nakayama; Hiromi Muta; Shinichi Somada; Toyoki Maeda; Toshitaka Mutoh; Kanako Shimizu; Yoko Suehiro; Terumasa Hisano; Ryo Kurita; Takeshi Shiraishi; Masaki Mori; Yasuji Yoshikawa; Nobuto Tsunetomi; Akihiro Uchida; Kenzaburo Tani

doi:10.2169/internalmedicine.46.1735

CASE REPORTS

Cronkhite-Canada Syndrome Associated with Schizophrenia

Masaharu Nakayama, Hiromi Muta, Shinichi Somada, Toyoki Maeda, Toshitaka Mutoh, Kanako Shimizu, Yoko Suehiro, Terumasa Hisano, Ryo Kurita, Takeshi Shiraishi, Masaki Mori, Yasuji Yoshikawa, Nobuto Tsunetomi, Akihiro Uchida, Kenzaburo Tani

Author information

Masaharu Nakayama
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Hiromi Muta
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Shinichi Somada
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Toyoki Maeda
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Toshitaka Mutoh
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Kanako Shimizu
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Yoko Suehiro
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Terumasa Hisano
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Ryo Kurita
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Takeshi Shiraishi
Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University
Masaki Mori
Department of Molecular and Cellular Biology, Division of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University
Yasuji Yoshikawa
Division of Clinical Laboratory, Medical Institute of Bioregulation, Kyushu University
Nobuto Tsunetomi
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University
Division of Clinical Laboratory, Medical Institute of Bioregulation, Kyushu University
Department of Gastroenterology, Shin Beppu Hospital
Akihiro Uchida
Uchida Hospital
Kenzaburo Tani
Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, and Department of Molecular Genetics, Division of Molecular and Clinical Genetics, Medical Institute of Bioregulation, Kyushu University

Keywords: Cronkhite-Canada syndrome, endoscopic ultrasonography, schizophrenia

JOURNAL OPEN ACCESS

2007 Volume 46 Issue 4 Pages 175-180

DOI https://doi.org/10.2169/internalmedicine.46.1735

Details

Abstract

Here, we report a case of Cronkhite-Canada syndrome in a patient with schizophrenia. A 64-year-old man, who had been diagnosed as having a schizophrenic disorder at the age of 30, presented with alopecia, atrophic nail changes, hyperpigmentation of the skin, and inflammatory polyposis of the stomach and colon. Endoscopic ultrasonography of the stomach and colon revealed diffuse mucosal thickening with small hypoechoic areas, corresponding to edema of the lamina propria. After treatment with parenteral hyperalimentation and tranexamic acid, his physical findings and polyposis gradually improved. This is the first report of Cronkhite-Canada syndrome in a patient with schizophrenia.

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