Adenoid Cystic Carcinoma of the Lung with an EGFR Mutation

Masaki Fujita; Takemasa Matsumoto; Ryosuke Hirano; Junji Uchino; Takako Hirota; Etsuro Yamaguchi; Akihito Kubo; Toyoharu Yokoi; Kazuki Nabeshima; Kentaro Watanabe

doi:10.2169/internalmedicine.55.6592

CASE REPORTS

Adenoid Cystic Carcinoma of the Lung with an EGFR Mutation

Masaki Fujita, Takemasa Matsumoto, Ryosuke Hirano, Junji Uchino, Takako Hirota, Etsuro Yamaguchi, Akihito Kubo, Toyoharu Yokoi, Kazuki Nabeshima, Kentaro Watanabe

Author information

Masaki Fujita
Department of Respiratory Medicine, Faculty of Medicine, Fukuoka University, Japan
Takemasa Matsumoto
Department of Respiratory Medicine, Faculty of Medicine, Fukuoka University, Japan
Ryosuke Hirano
Department of Respiratory Medicine, Faculty of Medicine, Fukuoka University, Japan
Junji Uchino
Department of Respiratory Medicine, Faculty of Medicine, Fukuoka University, Japan
Takako Hirota
Department of Respiratory Medicine, Faculty of Medicine, Fukuoka University, Japan
Etsuro Yamaguchi
Division of Respiratory Medicine and Allergology, Department of Internal Medicine, Aichi Medical University School of Medicine, Japan
Akihito Kubo
Division of Respiratory Medicine and Allergology, Department of Internal Medicine, Aichi Medical University School of Medicine, Japan
Toyoharu Yokoi
Division of Pathology, Department of Internal Medicine, Aichi Medical University School of Medicine, Japan
Kazuki Nabeshima
Department of Pathology, Faculty of Medicine, Fukuoka University, Japan
Kentaro Watanabe
Department of Respiratory Medicine, Faculty of Medicine, Fukuoka University, Japan

Keywords: lung cancer, EGFR, salivary gland, adenoid cystic carcinoma

JOURNAL OPEN ACCESS

2016 Volume 55 Issue 12 Pages 1621-1624

DOI https://doi.org/10.2169/internalmedicine.55.6592

Details

Abstract

An 80-year-old woman was referred to our hospital due to the presence of a mass that was identified on a chest X-ray. A further investigation demonstrated advanced adenoid cystic carcinoma of the lungs. Anti-cancer chemotherapy with docetaxel was carried out and the lesion remained as stable disease. Subsequently, pleural effusion was detected, and an investigation of the pleural effusion revealed the existence of malignant cells with an epidermal growth factor (EGFR) mutation. Gefitinib was administered and the pleural effusion resolved. This is the first case of a positive EGFR mutation of adenoid cystic carcinoma of the lung with a favorable response to an EGFR-tyrosine kinase inhibitor.

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