Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of Helicobacter pylori Infection

Shuichi Miyamoto; Mototsugu Kato; Kana Matsuda; Satoshi Abiko; Momoko Tsuda; Takeshi Mizushima; Keiko Yamamoto; Shoko Ono; Takahiko Kudo; Yuichi Shimizu; Kanako C. Hatanaka; Izumi Tsunematsu; Naoya Sakamoto

doi:10.2169/internalmedicine.56.8040

CASE REPORTS

Gastric Hyperplastic Polyps Associated with Proton Pump Inhibitor Use in a Case without a History of Helicobacter pylori Infection

Shuichi Miyamoto, Mototsugu Kato, Kana Matsuda, Satoshi Abiko, Momoko Tsuda, Takeshi Mizushima, Keiko Yamamoto, Shoko Ono, Takahiko Kudo, Yuichi Shimizu, Kanako C. Hatanaka, Izumi Tsunematsu, Naoya Sakamoto

Author information

Shuichi Miyamoto
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan
Mototsugu Kato
National Hospital Organization Hakodate Hospital, Japan
Kana Matsuda
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan
Satoshi Abiko
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan
Momoko Tsuda
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan
Takeshi Mizushima
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan
Keiko Yamamoto
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan
Shoko Ono
Division of Endoscopy, Hokkaido University Hospital, Japan
Takahiko Kudo
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan
Yuichi Shimizu
Division of Endoscopy, Hokkaido University Hospital, Japan
Kanako C. Hatanaka
Department of Surgical Pathology, Hokkaido University Hospital, Japan
Izumi Tsunematsu
Department of Internal Medicine, Toei Hospital, Japan
Naoya Sakamoto
Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Japan

Keywords: gastric hyperplastic polyp, Helicobacter pylori, proton pump inhibitor, gastrin receptor, gastrin

JOURNAL OPEN ACCESS

2017 Volume 56 Issue 14 Pages 1825-1829

DOI https://doi.org/10.2169/internalmedicine.56.8040

Details

Abstract

A 56-year-old man with gastroesophageal reflux disease (GERD) was referred to our hospital. Esophagogastroduodenoscopy (EGD) revealed no evidence of any polypoid lesions in the stomach, and the patient had no history of Helicobacter pylori infection. He received omeprazole (20 mg) once daily for the GERD. EGD was performed at 1 year after the start of omeprazole administration, and this time, gastric hyperplastic polyps (GHPs) were detected. The GHPs increased in size as the omeprazole treatment continued, but they markedly decreased in size following omeprazole discontinuation. Thus, the administration of proton pump inhibitors may be a risk factor for the development of GHP independent of H. pylori infection.

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