Abstract
The chronic inflammation process that characterises atherosclerosis involves both the innate and adaptive arms of the immune system. Several lines of evidence have recently highlighted pivotal roles for T and B lymphocytes – cells that belong to the adaptive immune system – in the development and progression of atherosclerosis. In this review, we summarise the current knowledge on the roles of adaptive immune responses in atherosclerosis and present our views on how a better understanding of these immune mechanisms could shape future therapies to slow down or even prevent this disease.
Keywords: Adaptive immune response, T cells, B cells, atherosclerosis, metallo-proteinases (MMPs), acute coronary syndrome (ACS), macrophages, monoclonal antibody, rheumatoid arthritis, systemic lupus erythematosus
Current Pharmaceutical Design
Title: The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications
Volume: 17 Issue: 37
Author(s): I. E. Dumitriu and J. C. Kaski
Affiliation:
Keywords: Adaptive immune response, T cells, B cells, atherosclerosis, metallo-proteinases (MMPs), acute coronary syndrome (ACS), macrophages, monoclonal antibody, rheumatoid arthritis, systemic lupus erythematosus
Abstract: The chronic inflammation process that characterises atherosclerosis involves both the innate and adaptive arms of the immune system. Several lines of evidence have recently highlighted pivotal roles for T and B lymphocytes – cells that belong to the adaptive immune system – in the development and progression of atherosclerosis. In this review, we summarise the current knowledge on the roles of adaptive immune responses in atherosclerosis and present our views on how a better understanding of these immune mechanisms could shape future therapies to slow down or even prevent this disease.
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Cite this article as:
E. Dumitriu I. and C. Kaski J., The Role of T and B Cells in Atherosclerosis: Potential Clinical Implications, Current Pharmaceutical Design 2011; 17 (37) . https://dx.doi.org/10.2174/138161211798764834
DOI https://dx.doi.org/10.2174/138161211798764834 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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