Random Sequence Libraries Displayed on Phage: Identification of Biologically Important Molecules

Christopher   G.   Adda; Robin   F.   Anders; Leann      Tilley; Michael      Foley

doi:10.2174/1386207023330561

Abstract

Phage display has become a widely used tool for the identification of proteins or peptides with affinity for a variety of biomolecules. The versatility, simplicity and cost effectiveness of this application has pervaded a wide variety of research areas. Although not without its limitations, phage display has provided a convenient methodology for obtaining ligands to study the function, structure and diagnostic or therapeutic potential of various macromolecules. This review highlights some recent research employing this technology that serves to illustrate its utility in various research and clinical applications.

Keywords: Phage display, biopannig, tissue-type plasminogen activator

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Combinatorial Chemistry & High Throughput Screening

Title: Random Sequence Libraries Displayed on Phage: Identification of Biologically Important Molecules

Volume: 5 Issue: 1

Author(s): Christopher G. Adda, Robin F. Anders, Leann Tilley and Michael Foley

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Keywords: Phage display, biopannig, tissue-type plasminogen activator

Abstract: Phage display has become a widely used tool for the identification of proteins or peptides with affinity for a variety of biomolecules. The versatility, simplicity and cost effectiveness of this application has pervaded a wide variety of research areas. Although not without its limitations, phage display has provided a convenient methodology for obtaining ligands to study the function, structure and diagnostic or therapeutic potential of various macromolecules. This review highlights some recent research employing this technology that serves to illustrate its utility in various research and clinical applications.

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Adda G. Christopher, Anders F. Robin, Tilley Leann and Foley Michael, Random Sequence Libraries Displayed on Phage: Identification of Biologically Important Molecules, Combinatorial Chemistry & High Throughput Screening 2002; 5 (1) . https://dx.doi.org/10.2174/1386207023330561

DOI https://dx.doi.org/10.2174/1386207023330561	Print ISSN 1386-2073
Publisher Name Bentham Science Publisher	Online ISSN 1875-5402

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