Abstract
Human interferon-stimulated gene 15 (ISG15) is a 15-kDa ubiquitin-like protein that can be detected as either free ISG15 or covalently associated with its target proteins through a process termed ISGylation. Interestingly, extracellular free ISG15 has been proposed as a cytokinelike protein, whereas ISGylation is a posttranslational modification. ISG15 is a small protein with implications in some biological processes and pathologies that include cancer. This review highlights the findings of both free ISG15 and protein ISGylation involved in several molecular pathways, emerging as central elements in some cancer types.
Keywords: Free ISG15, conjugated ISG15, ISGylation system, cancer, proteins, molecular pathways.
Current Protein & Peptide Science
Title:Molecular Pathways of Interferon-Stimulated Gene 15: Implications in Cancer
Volume: 22 Issue: 1
Author(s): Angeles C. Tecalco-Cruz*
Affiliation:
- Programa en Ciencias Genomicas, Universidad Autonoma de la Ciudad de Mexico (UACM), Apdo. Postal 03100, Ciudad de Mexico,Mexico
Keywords: Free ISG15, conjugated ISG15, ISGylation system, cancer, proteins, molecular pathways.
Abstract: Human interferon-stimulated gene 15 (ISG15) is a 15-kDa ubiquitin-like protein that can be detected as either free ISG15 or covalently associated with its target proteins through a process termed ISGylation. Interestingly, extracellular free ISG15 has been proposed as a cytokinelike protein, whereas ISGylation is a posttranslational modification. ISG15 is a small protein with implications in some biological processes and pathologies that include cancer. This review highlights the findings of both free ISG15 and protein ISGylation involved in several molecular pathways, emerging as central elements in some cancer types.
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Cite this article as:
Tecalco-Cruz C. Angeles*, Molecular Pathways of Interferon-Stimulated Gene 15: Implications in Cancer, Current Protein & Peptide Science 2021; 22 (1) . https://dx.doi.org/10.2174/1389203721999201208200747
DOI https://dx.doi.org/10.2174/1389203721999201208200747 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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