Abstract
Drug response is affected by genetic and non-genetic factors, such as dietary compounds, sex, disease status and multiple drug therapy. Inherited determinants of drug disposition remain, however, the major cause of inter-individual differences due to pharmacogenetic polymorphism in drug metabolizing enzymes and transporters, or drug targets. Differences on ethnicity may have a profound impact on drug clearance, affecting the safety, efficacy and dosing regimen. In the context of tropical regions, the situation may be even more serious due to endemic infectious diseases and multiple drug therapy, which may affect drug clearance. In this review, we focus on the pharmacogenetics of the Cytochrome P450 superfamily, responsible for the highest contribution for variability among drug metabolizing enzymes, among ethnic groups from tropical settings.
Keywords: Pharmacogenetics, Cytochrome P450, tropical, ethnic, Africa, Southeast Asia, Latin America
Current Drug Targets
Title: Pharmacogenetics of Cytochromes P450 in Tropical Medicine
Volume: 7 Issue: 12
Author(s): V. Ribeiro and I. Cavaco
Affiliation:
Keywords: Pharmacogenetics, Cytochrome P450, tropical, ethnic, Africa, Southeast Asia, Latin America
Abstract: Drug response is affected by genetic and non-genetic factors, such as dietary compounds, sex, disease status and multiple drug therapy. Inherited determinants of drug disposition remain, however, the major cause of inter-individual differences due to pharmacogenetic polymorphism in drug metabolizing enzymes and transporters, or drug targets. Differences on ethnicity may have a profound impact on drug clearance, affecting the safety, efficacy and dosing regimen. In the context of tropical regions, the situation may be even more serious due to endemic infectious diseases and multiple drug therapy, which may affect drug clearance. In this review, we focus on the pharmacogenetics of the Cytochrome P450 superfamily, responsible for the highest contribution for variability among drug metabolizing enzymes, among ethnic groups from tropical settings.
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Cite this article as:
Ribeiro V. and Cavaco I., Pharmacogenetics of Cytochromes P450 in Tropical Medicine, Current Drug Targets 2006; 7 (12) . https://dx.doi.org/10.2174/138945006779025347
DOI https://dx.doi.org/10.2174/138945006779025347 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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