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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

The Wide Pharmacological Versatility of Semicarbazones, Thiosemicarbazones and Their Metal Complexes

Author(s): H. Beraldo and D. Gambinob

Volume 4, Issue 1, 2004

Page: [31 - 39] Pages: 9

DOI: 10.2174/1389557043487484

Price: $65

Abstract

The more significant bioactivities of a variety of semicarbazones (anti-protozoa, anticonvulsant) and thiosemicarbazones (antibacterial, antifungal, antitumoral, antiviral) and their metal complexes are reviewed together with proposed mechanisms of action and structure-activity relationships. Clinical or potential pharmacological applications of these versatile compounds are discussed.

Keywords: Semicarbazones, thiosemicarbazones, biological activity, pharmacological applications, bioactive metal complexes, mechanisms of action


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