Abstract
In this review, we show Angiotensin-(1-7) as a novel Renin Angiotensin System mediator that antagonizes cardiovascular and proliferative effects of Angiotensin II and exerts complex renal actions. We also speculate the possibility of new drugs for the treatment of cardiovascular, genitourinary and hepatic diseases by interfering with ACE2- Angiotensin-(1-7)-Mas axis.
Keywords: Angiotensin-(1-7), Mas receptor, Angiotensin-converting enzyme 2, Angiotensin II, AVE 0991, Angiotensin antagonists, Renin-Angiotensin System
Mini-Reviews in Medicinal Chemistry
Title: The Therapeutic Potential of Angiotensin-(1-7) as a Novel Renin- Angiotensin System Mediator
Volume: 6 Issue: 5
Author(s): Ana C. S. e Silva, Sergio V. B. Pinheiro, Regina M. Pereira, Anderson J. Ferreira and Robson A. S. Santos
Affiliation:
Keywords: Angiotensin-(1-7), Mas receptor, Angiotensin-converting enzyme 2, Angiotensin II, AVE 0991, Angiotensin antagonists, Renin-Angiotensin System
Abstract: In this review, we show Angiotensin-(1-7) as a novel Renin Angiotensin System mediator that antagonizes cardiovascular and proliferative effects of Angiotensin II and exerts complex renal actions. We also speculate the possibility of new drugs for the treatment of cardiovascular, genitourinary and hepatic diseases by interfering with ACE2- Angiotensin-(1-7)-Mas axis.
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Cite this article as:
e Silva C. S. Ana, Pinheiro V. B. Sergio, Pereira M. Regina, Ferreira J. Anderson and Santos A. S. Robson, The Therapeutic Potential of Angiotensin-(1-7) as a Novel Renin- Angiotensin System Mediator, Mini-Reviews in Medicinal Chemistry 2006; 6 (5) . https://dx.doi.org/10.2174/138955706776876203
DOI https://dx.doi.org/10.2174/138955706776876203 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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