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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Interactions of Polyphenols with the P450 System: Possible Implications on Human Therapeutics

Author(s): M. J. Gomez-Lechon, I. Rodeiro, M. T. Donato, A. Lahoz, G. Garrido and R. Delgado

Volume 8, Issue 2, 2008

Page: [97 - 106] Pages: 10

DOI: 10.2174/138955708783498131

Price: $65

Abstract

Polyphenols are a family of natural compounds with many biological properties. This review focuses on their potential interaction on the cytochrome P450 system. Effects of phenolic acids, anthocyanins, stilbenes, catechins and other flavonoids on the drug metabolising function are revised. Their daily intake and presence in herbal medicines justify the study of potential drug-interaction to prevent undesirable clinical consequences.

Keywords: Antioxidants, flavonoids, polyphenols, cytochrome P450, herbal medicines


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