Abstract
Objective: Prosody, an important aspect of spoken language, is defined as the emphasis placed on certain syllables, changes in tempo or timing, and variance in pitch and intonation. Most studies investigating expression and comprehension of prosody have focused primarily on emotional prosody and less extensively on supralexical prosody. The distinction is indeed important, as the latter conveys information such as interrogative or assertive mode, whereas the former delivers emotional connotation, such as happiness, anger, and sadness. These functions appear to rely on distinct neuronal networks, supported by functional neuroimaging studies that show activation of the right hemisphere, specifically in the right inferior frontal area during emotional detection.
Conclusion: This review summarizes the studies conducted on prosody impairment in Alzheimer's disease and other dementias, with emphasis on experiments designed to investigate the emotional vs. the supralexical aspect of speech production. We also discussed the available tools validated to test and quantify the prosodic impairment.
Keywords: Alzheimer's disease, dementia, frontotemporal dementia, language, mild cognitive impairment, prosody.
Current Alzheimer Research
Title:Prosodic Impairment in Dementia: Review of the Literature
Volume: 15 Issue: 2
Author(s): Sylwia Misiewicz , Adam M. Brickman and Giuseppe Tosto *
Affiliation:
- G.H. Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY,United States
Keywords: Alzheimer's disease, dementia, frontotemporal dementia, language, mild cognitive impairment, prosody.
Abstract: Objective: Prosody, an important aspect of spoken language, is defined as the emphasis placed on certain syllables, changes in tempo or timing, and variance in pitch and intonation. Most studies investigating expression and comprehension of prosody have focused primarily on emotional prosody and less extensively on supralexical prosody. The distinction is indeed important, as the latter conveys information such as interrogative or assertive mode, whereas the former delivers emotional connotation, such as happiness, anger, and sadness. These functions appear to rely on distinct neuronal networks, supported by functional neuroimaging studies that show activation of the right hemisphere, specifically in the right inferior frontal area during emotional detection.
Conclusion: This review summarizes the studies conducted on prosody impairment in Alzheimer's disease and other dementias, with emphasis on experiments designed to investigate the emotional vs. the supralexical aspect of speech production. We also discussed the available tools validated to test and quantify the prosodic impairment.
Export Options
About this article
Cite this article as:
Misiewicz Sylwia , Brickman M. Adam and Tosto Giuseppe *, Prosodic Impairment in Dementia: Review of the Literature, Current Alzheimer Research 2018; 15 (2) . https://dx.doi.org/10.2174/1567205014666171030115624
DOI https://dx.doi.org/10.2174/1567205014666171030115624 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
New Advances in the Prevention, Diagnosis, Treatment, and Rehabilitation of Alzheimer's Disease
Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
Diagnostic and therapeutic biomarkers of dementia
Dementia affects 18 million people worldwide. Dementia is a syndrome of symptoms caused by brain disease, usually chronic or progressive, clinically characterized by multiple impairments of higher cortical functions such as memory, thinking, orientation, and learning. In addition, in the course of dementia, cognitive deficits are observed, which often hinder ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Adverse Events of Proton Pump Inhibitors: Potential Mechanisms
Current Drug Metabolism Differential Expression of Ribosomal Genes in Brain and Blood of Alzheimer’s Disease Patients
Current Alzheimer Research Cervical Cancer Diagnosis: Insights into Biochemical Biomarkers and Imaging Techniques
Combinatorial Chemistry & High Throughput Screening Purinergic Signalling and Endothelium
Current Vascular Pharmacology HSV Amplicons: Neuro Applications
Current Gene Therapy Current and Future of Alzheimer's Therapy with the Best Approach
CNS & Neurological Disorders - Drug Targets Designing of Selective γ-Secretase Inhibitory Benzenesulfonamides through Comparative In Vitro and In Silico Analysis
Current Drug Discovery Technologies Anti-Alzheimer, Antioxidant Activities and Flavonol Glycosides of Eryngium campestre L.
Current Chemical Biology Patenting Penicillium Strains
Recent Patents on Biotechnology Medical Management of Parkinsons Disease: Focus on Neuroprotection
Current Neuropharmacology From Antioxidant Chelators to Site-Activated Multi-Target Chelators Targeting Hypoxia Inducing Factor, Beta-Amyloid, Acetylcholinesterase and Monoamine Oxidase A/B
Mini-Reviews in Medicinal Chemistry The Differential Diagnostic Value of the Callosal Angle and Evans Index in Mild Cognitive Impairment and Alzheimer's Disease
Current Medical Imaging Cornel Iridoid Glycoside Suppresses Tau Hyperphosphorylation and Aggregation in a Mouse Model of Tauopathy through Increasing Activity of PP2A
Current Alzheimer Research The Role of Stem Cell Factor and Granulocyte-Colony Stimulating Factor in Treatment of Stroke
Recent Patents on CNS Drug Discovery (Discontinued) Factor VIII Levels are Associated with Ischemic Stroke, Stroke Subtypes and Neurological Worsening
Current Neurovascular Research α-Melanocyte Stimulating Hormone as a Potential Therapy for Alzheimer's Disease
Current Alzheimer Research Adiponectin as a Target in Obesity-related Inflammatory State
Endocrine, Metabolic & Immune Disorders - Drug Targets Heightened Attention for Wnt Signaling in Diabetes Mellitus
Current Neurovascular Research HIV-1 Induced CNS Dysfunction: Current Overview and Research Priorities
Current HIV Research Strain Specificity and Drug Resistance in Anti-Prion Therapy
Current Topics in Medicinal Chemistry