Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection

Title:Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection

Volume: 15 Issue: 5

Author(s): Upinder Kaur, Priyanjalee Banerjee, Aritri Bir, Maitrayee Sinha, Atanu Biswas and Sasanka Chakrabarti

Affiliation:

Keywords: Alzheimer’s disease, Amyloid beta, Cytokines, NF-κB, Oxidative stress, Redox signaling.

Abstract: Oxidative stress and inflammatory response are important elements of Alzheimer's disease (AD) pathogenesis, but the role of redox signaling cascade and its cross-talk with inflammatory mediators have not been elucidated in details in this disorder. The review summarizes the facts about redox-signaling cascade in the cells operating through an array of kinases, phosphatases and transcription factors and their downstream components. The biology of NF-κB and its activation by reactive oxygen species (ROS) and proinflammatory cytokines in the pathogenesis of AD have been specially highlighted citing evidence both from post-mortem studies in AD brain and experimental research in animal or cell-based models of AD. The possibility of identifying new disease-modifying drugs for AD targeting NF-κBsignaling cascade has been discussed in the end.

Cite this article as:

Kaur Upinder, Banerjee Priyanjalee, Bir Aritri, Sinha Maitrayee, Biswas Atanu and Chakrabarti Sasanka, Reactive Oxygen Species, Redox Signaling and Neuroinflammation in Alzheimer's Disease: The NF-κB Connection, Current Topics in Medicinal Chemistry 2015; 15 (5) . https://dx.doi.org/10.2174/1568026615666150114160543