Abstract
This investigation reports on the drug interactions between chitosans and antibiotics in Staphylococcus aureus. The combination study shows that chitosan oligosaccharides have synergistic effect in combination with tetracycline, ceftriazone and sulfamethoxazole. Also, high molecular weight chitosan was found to be effective against Staphylococcus aureus in combination with Sulfamethoxawzole. These results indicate the potential efficacy of chitosans in combinations with antibiotics for enhancing total biological activity.
Keywords: Synergy, Additive, Combination therapy, Chitosan, chitin, Drug resistance
Letters in Drug Design & Discovery
Title: Synergistic Combinations of Chitosans and Antibiotics in Staphylococcus aureus
Volume: 7 Issue: 1
Author(s): San Tin, Chu Sing Lim, Meena Kishore Sakharkar and Kishore Ramaji Sakharkar
Affiliation:
Keywords: Synergy, Additive, Combination therapy, Chitosan, chitin, Drug resistance
Abstract: This investigation reports on the drug interactions between chitosans and antibiotics in Staphylococcus aureus. The combination study shows that chitosan oligosaccharides have synergistic effect in combination with tetracycline, ceftriazone and sulfamethoxazole. Also, high molecular weight chitosan was found to be effective against Staphylococcus aureus in combination with Sulfamethoxawzole. These results indicate the potential efficacy of chitosans in combinations with antibiotics for enhancing total biological activity.
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Cite this article as:
Tin San, Lim Sing Chu, Sakharkar Kishore Meena and Sakharkar Ramaji Kishore, Synergistic Combinations of Chitosans and Antibiotics in Staphylococcus aureus, Letters in Drug Design & Discovery 2010; 7 (1) . https://dx.doi.org/10.2174/157018010789869406
DOI https://dx.doi.org/10.2174/157018010789869406 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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