Abstract
Background: Damage to the myelin sheath (demyelination) is one of the main manifestations of multiple sclerosis (MS). Interestingly, both MS and vitamin B deficiencies result in severe myelin degeneration, leading to loss in neuronal signal transmission.
Objective: Deficiency in vitamin B complex vary, although common symptoms include fatigue, increased oxidative stress, inflammation and demyelination. In particular, vitamin B12 (cobalamin) has had increased attention for its role in the methylation process, involvement in myelination and remyelination, and reversal of MS symptoms.
Method: Here, we discuss the role of vitamin B complex (B1, B2, B3, B4, B5, B6, B7, B9, B12) in MS.
Results: The anti-inflammatory and re-myelinating attributes of vitamin B complex members are promising, despite limited clinical studies.
Conclusion: There is an urgent need for larger studies to determine the role of vitamin B supplementation alone, or in combination with other therapeutic agents, in prevention or reversal of MS, and aid in improved quality of life of MS patients.
Keywords: Cobalamin, EAE, folate, multiple sclerosis, niacin, pantothenic acid, riboflavin, thiamin, vitamin B.
Medicinal Chemistry
Title:Is there a Link between Vitamin B and Multiple Sclerosis?
Volume: 14 Issue: 2
Author(s): Natalie Nemazannikova, Kathleen Mikkelsen, Lily Stojanovska, Gregory L. Blatch and Vasso Apostolopoulos*
Affiliation:
- Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne,Australia
Keywords: Cobalamin, EAE, folate, multiple sclerosis, niacin, pantothenic acid, riboflavin, thiamin, vitamin B.
Abstract: Background: Damage to the myelin sheath (demyelination) is one of the main manifestations of multiple sclerosis (MS). Interestingly, both MS and vitamin B deficiencies result in severe myelin degeneration, leading to loss in neuronal signal transmission.
Objective: Deficiency in vitamin B complex vary, although common symptoms include fatigue, increased oxidative stress, inflammation and demyelination. In particular, vitamin B12 (cobalamin) has had increased attention for its role in the methylation process, involvement in myelination and remyelination, and reversal of MS symptoms.
Method: Here, we discuss the role of vitamin B complex (B1, B2, B3, B4, B5, B6, B7, B9, B12) in MS.
Results: The anti-inflammatory and re-myelinating attributes of vitamin B complex members are promising, despite limited clinical studies.
Conclusion: There is an urgent need for larger studies to determine the role of vitamin B supplementation alone, or in combination with other therapeutic agents, in prevention or reversal of MS, and aid in improved quality of life of MS patients.
Export Options
About this article
Cite this article as:
Nemazannikova Natalie , Mikkelsen Kathleen, Stojanovska Lily , Blatch L. Gregory and Apostolopoulos Vasso *, Is there a Link between Vitamin B and Multiple Sclerosis?, Medicinal Chemistry 2018; 14 (2) . https://dx.doi.org/10.2174/1573406413666170906123857
DOI https://dx.doi.org/10.2174/1573406413666170906123857 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
Call for Papers in Thematic Issues
Carbohydrates in Computational and Medicinal Chemistry
Carbohydrates are the most essential organic molecules and are involved in the maintenance of various physiological and metabolic processes in living organisms. Carbohydrate-based compounds have come to the attention of researchers because of their significant contributions to biological functions, such as cell development and cell proliferation, connections between several cells, ...read more
Recent Advances in the Medicinal Chemistry of Cancer
Scope of the Thematic Issue: Correlation between structure and function is one of the important aspects of the success of anti-cancer compounds associated with their structure-activity interactions, physiology, biochemical, molecular, and genetic processes. Overcoming these obstacles is key to obtaining further insights into developments in rational drug design, bioorganic chemistry, ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Sumoylation Pathway as Potential Therapeutic Targets in Cancer
Current Molecular Medicine Ventilatory Response to Hypercapnia as Experimental Model to Study Effects of Oxycodone on Respiratory Depression
Current Reviews in Clinical and Experimental Pharmacology Recent Advancement of Direct-acting Antiviral Agents (DAAs) in Hepatitis C Therapy
Mini-Reviews in Medicinal Chemistry Anticancer Mammalian Target of Rapamycin (mTOR) Signaling Pathway Inhibitors: Current Status, Challenges and Future Prospects in Management of Epilepsy
CNS & Neurological Disorders - Drug Targets Conformational Changes in HIV-1 Reverse Transcriptase Induced by Nonnucleoside Reverse Transcriptase Inhibitor Binding
Current HIV Research Targeting Opioid and Neurokinin-1 Receptors to Treat Alcoholism
Current Medicinal Chemistry Increasing Neurogenesis with Fluoxetine, Simvastatin and Ascorbic Acid Leads to Functional Recovery in Ischemic Stroke
Recent Patents on Drug Delivery & Formulation Weight Gain and Metabolic Changes During Treatment with Antipsychotics and Antidepressants
Endocrine, Metabolic & Immune Disorders - Drug Targets Metabolic Syndrome, Mild Cognitive Impairment and Dementia
Current Alzheimer Research Hippocampal-Dependent Inhibitory Learning and Memory Processes in the Control of Eating and Drug Taking
Current Pharmaceutical Design B Cells: Programmers of CD4 T Cell Responses
Infectious Disorders - Drug Targets Immune Responses to Gene Product of Inducible Promoters
Current Gene Therapy Methylphenidate in Adults with Attention Deficit Hyperactivity Disorder and Substance Use Disorders
Current Pharmaceutical Design Oxidative Stress in the Hypothalamus: the Importance of Calcium Signaling and Mitochondrial ROS in Body Weight Regulation
Current Neuropharmacology Cognitive Abilities of Alzheimers Disease Transgenic Mice are Modulated by Social Context and Circadian Rhythm
Current Alzheimer Research The Putative Neuroprotective Role of Neuropeptide Y in the Central Nervous System
Current Drug Targets - CNS & Neurological Disorders Reactive Oxygen Species Formation by Polymorphonuclear Cells and Mononuclear Cells as a Risk Factor of Cardiovascular Diseases
Current Pharmaceutical Biotechnology Biomarkers of Major Depression Related to Serotonin Receptors
Current Psychiatry Reviews Infectious Agents and Neurodegenerative Diseases: Exploring the Links
Current Topics in Medicinal Chemistry Cytokines in the Central Nervous System: Targets for Therapeutic Intervention
Current Drug Targets - CNS & Neurological Disorders