Abstract
The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.
Keywords: Filoviridae, Ebola virus, Marburg virus, drug targets, therapeutics, pathogenesis, pathology, immunotherapy
Infectious Disorders - Drug Targets
Title: Drug Targets in Infections with Ebola and Marburg Viruses
Volume: 9 Issue: 2
Author(s): Olinger G. Gene, Biggins E. Julia, Melanson R. Vanessa, Wahl-Jensen Victoria, Geisbert W. Thomas and Hensley E. Lisa
Affiliation:
Keywords: Filoviridae, Ebola virus, Marburg virus, drug targets, therapeutics, pathogenesis, pathology, immunotherapy
Abstract: The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.
Export Options
About this article
Cite this article as:
Gene G. Olinger, Julia E. Biggins, Vanessa R. Melanson, Victoria Wahl-Jensen, Thomas W. Geisbert and Lisa E. Hensley, Drug Targets in Infections with Ebola and Marburg Viruses, Infectious Disorders - Drug Targets 2009; 9 (2) . https://dx.doi.org/10.2174/187152609787847730
DOI https://dx.doi.org/10.2174/187152609787847730 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Nitric Oxide and Cyclic GMP Signaling Pathway as a Focus for Drug Development
Current Medicinal Chemistry Possible Mechanisms of Lymphoma Development in Sjogren’s Syndrome
Current Immunology Reviews (Discontinued) Management of Connective Tissue Interstitial Lung Disease
Current Respiratory Medicine Reviews Anesthetic Pharmacology and Perioperative Considerations for Heart Transplantation
Current Clinical Pharmacology T Cell Receptor Bias in Humans
Current Immunology Reviews (Discontinued) Antioxidants in Peripheral Arterial Disease
Current Drug Targets - Cardiovascular & Hematological Disorders Beneficial Role of Vitexin and Isovitexin Flavonoids in the Vascular Endothelium and Cardiovascular System
Current Nutraceuticals Vascular Damage in Impaired Glucose Tolerance: An Unappreciated Phenomenon?
Current Pharmaceutical Design Imaging Features of Thoracic Manifestations of Behçet’s Disease: Beyond Pulmonary Artery Involvement
Current Medical Imaging The Role of Angiotensin in Obesity and Metabolic Disease
Endocrine, Metabolic & Immune Disorders - Drug Targets The Use of Interferons in Respiratory Diseases
Current Respiratory Medicine Reviews Primary Antiphospholipid Syndrome and Pulmonary Hypertension
Current Pharmaceutical Design Rationale for Peptide and DNA Based Epitope Vaccines for Alzheimers Disease Immunotherapy
CNS & Neurological Disorders - Drug Targets Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice
Current Medicinal Chemistry Rheumatic Manifestations Associated with Inflammatory Bowel Diseases
Current Rheumatology Reviews Vasopressin Secretion Control: Central Neural Pathways, Neurotransmitters and Effects of Drugs
Current Pharmaceutical Design Depression as a Comorbidity in Behcet's Syndrome
CNS & Neurological Disorders - Drug Targets Innate and Adaptive Immune Responses in Chronic HCV Infection
Current Drug Targets The Relationship Between Social Support, Social Constraint, and Psychological Adjustment for Patients with Rare Autoimmune Disease
Current Rheumatology Reviews Cardiovascular Effects of Methotrexate in Rheumatoid Arthritis Revisited
Current Medicinal Chemistry