Abstract
Tea is a popular beverage with a number of putative beneficial health effects. A recent large epidemiological study in Japan demonstrates that increased tea consumption is associated with decreased cardiovascular mortality (but not cancer mortality) in a dose-dependent manner. The polyphenol epigallocatechin-3-gallate (EGCG) is the most abundant tea catechin. Beneficial effects of EGCG therapy have been reported in a number of human and animal studies. Emerging evidence suggests that EGCG may improve endothelial function, hypertension, coronary heart disease, obesity, insulin resistance, as well as glucose and lipid metabolism. Studies in cultured cells and animal models suggest molecular mechanisms for EGCG to activate specific cellular signaling pathways that may play major roles in prevention and amelioration of cardiovascular and metabolic diseases. In this review, the beneficial health effects of tea and molecular mechanisms of EGCG related to cardiovascular and metabolic diseases will be discussed.
Keywords: epigallocatechin, Hypertension, cardiovascular disease, epicatechin, mediated brachial artery dilation, Dyslipidemia
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title: Mechanisms Underlying Beneficial Health Effects of Tea Catechins to Improve Insulin Resistance and Endothelial Dysfunction
Volume: 8 Issue: 2
Author(s): Jeong-A. Kim
Affiliation:
Keywords: epigallocatechin, Hypertension, cardiovascular disease, epicatechin, mediated brachial artery dilation, Dyslipidemia
Abstract: Tea is a popular beverage with a number of putative beneficial health effects. A recent large epidemiological study in Japan demonstrates that increased tea consumption is associated with decreased cardiovascular mortality (but not cancer mortality) in a dose-dependent manner. The polyphenol epigallocatechin-3-gallate (EGCG) is the most abundant tea catechin. Beneficial effects of EGCG therapy have been reported in a number of human and animal studies. Emerging evidence suggests that EGCG may improve endothelial function, hypertension, coronary heart disease, obesity, insulin resistance, as well as glucose and lipid metabolism. Studies in cultured cells and animal models suggest molecular mechanisms for EGCG to activate specific cellular signaling pathways that may play major roles in prevention and amelioration of cardiovascular and metabolic diseases. In this review, the beneficial health effects of tea and molecular mechanisms of EGCG related to cardiovascular and metabolic diseases will be discussed.
Export Options
About this article
Cite this article as:
Kim Jeong-A., Mechanisms Underlying Beneficial Health Effects of Tea Catechins to Improve Insulin Resistance and Endothelial Dysfunction, Endocrine, Metabolic & Immune Disorders - Drug Targets 2008; 8 (2) . https://dx.doi.org/10.2174/187153008784534349
DOI https://dx.doi.org/10.2174/187153008784534349 |
Print ISSN 1871-5303 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3873 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Role of Platelets in Cardiovascular Disease: Molecular Mechanisms
Current Pharmaceutical Design Effect of Non-Statin Lipid Lowering and Anti-Obesity Drugs on LDL Subfractions in Patients with Mixed Dyslipidaemia
Current Vascular Pharmacology Hydrogen Sulfide as a New Endogenous Gaseous Transmitter in the Cardiovascular System
Current Vascular Pharmacology Chemokines in Cardiovascular Remodeling: Clinical and Therapeutic Implications
Current Molecular Medicine Unique Coronary Artery Disease Differences in Women as Related to Revascularization
Current Medicinal Chemistry Fullerenes: From Carbon to Nanomedicine
Mini-Reviews in Medicinal Chemistry “European Panel on Low Density Lipoprotein (LDL) Subclasses”: A Statement on the Pathophysiology, Atherogenicity and Clinical Significance of LDL Subclasses
Current Vascular Pharmacology Impact of Patient Knowledge of Hypertension Complications on Adherence to Antihypertensive Therapy
Current Hypertension Reviews Pre-CKD- Do we Need Another Hero?
Current Vascular Pharmacology Heart Failure Epidemiology: European Perspective
Current Cardiology Reviews The Double Roles of the Prostaglandin E<sub>2</sub> EP2 Receptor in Intracerebral Hemorrhage
Current Drug Targets Endothelial to Mesenchymal Transition in the Cardiogenesis and Cardiovascular Diseases
Current Cardiology Reviews Stem Cells Therapies in Basic Science and Translational Medicine: Current Status and Treatment Monitoring Strategies
Current Pharmaceutical Biotechnology Microbiome Regulation of Autoimmune, Gut and Liver Associated Diseases
Inflammation & Allergy - Drug Targets (Discontinued) Application of Dual-Source CT Coronary Angiography in Type 2 Diabetic Patients with Symptomatic Coronary Heart Disease
Current Vascular Pharmacology Challenges and Perspectives of Antiplatelet Therapy in Patients with Diabetes Mellitus and Coronary Artery Disease
Current Pharmaceutical Design Streptokinase: An Efficient Enzyme in Cardiac Medicine
Protein & Peptide Letters Influenza and Stroke Risk: A Key Target Not to be Missed?
Infectious Disorders - Drug Targets Drugs Designed to Improve Endothelial Function: Effects on Erectile Dysfunction
Current Pharmaceutical Design Treatment of Epileptic Encephalopathies
Current Pharmaceutical Design