Generic placeholder image

Recent Patents on Biotechnology

Editor-in-Chief

ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

Recent Patents on the Pichia Pastoris Expression System: Expanding the Toolbox for Recombinant Protein Production

Author(s): Monika Bollok, David Resina, Francisco Valero and Pau Ferrer

Volume 3, Issue 3, 2009

Page: [192 - 201] Pages: 10

DOI: 10.2174/187220809789389126

Price: $65

Abstract

Pichia pastoris is a widely used host system for heterologous protein expression both for basic research and industrial production purposes. Recent developments expanding the P. pastoris protein expression toolbox reflect the increasing interest in the application of yeast expression systems for protein-based pharmaceutical products, as an alternative to Escherichia coli and mammalian cell factories. The commonly used expression system for P. pastoris and, the recent patents relevant to the P. pastoris genetic toolbox for recombinant protein production are reviewed.

Keywords: Pichia pastoris, recombinant protein production, AOX1 promoter, secretion helper factors, N-glycosylation pathway engineering


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy