Abstract
MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression by targeting mRNAs and leading to either translation repression or RNA degradation. miRNAs have fundamental effects in the regulation of intracellular processes, and their importance during malignant transformation and metastasis is becoming increasingly well understood. The epithelial-mesenchymal transition (EMT), which reprograms tumor cells transcription, has been highlighted as a powerful process in tumor invasion, metastasis and tumorigenicity. In recent years, many studies have significantly enhanced our knowledge of EMT by the characterization of miRNAs that influence the signaling pathways and downstream events that define EMT on a molecular level. In this review, we detail the miRNAs and signal transduction pathways involved in the EMT process and demonstrate their importance in the study of cancer progression. We believe that this information will improve prognostication and reveal new opportunities for therapeutic intervention.
Keywords: EMT, miRNA, miR-200 family, P53, TGFβ signaling.
MicroRNA
Title:MicroRNAs Regulate the Epithelial to Mesenchymal Transition (EMT) in Cancer Progression
Volume: 3 Issue: 2
Author(s): Yang Hu and Hua Tang
Affiliation:
Keywords: EMT, miRNA, miR-200 family, P53, TGFβ signaling.
Abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression by targeting mRNAs and leading to either translation repression or RNA degradation. miRNAs have fundamental effects in the regulation of intracellular processes, and their importance during malignant transformation and metastasis is becoming increasingly well understood. The epithelial-mesenchymal transition (EMT), which reprograms tumor cells transcription, has been highlighted as a powerful process in tumor invasion, metastasis and tumorigenicity. In recent years, many studies have significantly enhanced our knowledge of EMT by the characterization of miRNAs that influence the signaling pathways and downstream events that define EMT on a molecular level. In this review, we detail the miRNAs and signal transduction pathways involved in the EMT process and demonstrate their importance in the study of cancer progression. We believe that this information will improve prognostication and reveal new opportunities for therapeutic intervention.
Export Options
About this article
Cite this article as:
Hu Yang and Tang Hua, MicroRNAs Regulate the Epithelial to Mesenchymal Transition (EMT) in Cancer Progression, MicroRNA 2014; 3 (2) . https://dx.doi.org/10.2174/2211536603666141010115102
DOI https://dx.doi.org/10.2174/2211536603666141010115102 |
Print ISSN 2211-5366 |
Publisher Name Bentham Science Publisher |
Online ISSN 2211-5374 |
Call for Papers in Thematic Issues
Modulatory Roles of Non-coding RNAs in cancer therapy
This thematic issue aims to elucidate the most recent research on ncRNAs in CRCs and discuss the importance and difficulties that may arise in applying this tool on a regular clinical basis.read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Melanoma: The Radiotherapeutic Point of View; Review of the Current Literature
Reviews on Recent Clinical Trials Genitourinary Tract Tumors in Children: An Update
Current Pediatric Reviews Design, Synthesis and Biological Evaluation of Novel 1,2,5-Oxadiazol-3- Carboximidamide Derivatives as Indoleamine 2, 3-Dioxygenase 1 (IDO1) Inhibitors
Anti-Cancer Agents in Medicinal Chemistry Gene Expression Signatures of Lymph Node Metastasis in Oral Cancer: Molecular Characteristics and Clinical Significances
Current Cancer Therapy Reviews Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults
Current Medicinal Chemistry Baicalein-Phospholipid Complex: A Novel Drug Delivery Technology for Phytotherapeutics
Current Drug Discovery Technologies Tumor-Induced Alterations in Lipid Metabolism
Current Medicinal Chemistry Synthesis and Biological Evaluation of Novel Thiazol-2yl-amine Derivatives as Potential Anticancer Agents
Letters in Organic Chemistry Update on the Development of microRNA and siRNA Molecules as Regulators of Cell Physiology
Recent Patents on DNA & Gene Sequences Intracellular Delivery of Potential Therapeutic Genes: Prospects in Cancer Gene Therapy
Current Gene Therapy Synthesis of 1,3,6-Trioxygenated Prenylated Xanthone Derivatives as Potential Antitumor Agents
Letters in Organic Chemistry DNA Repair Inhibitors: The Next Major Step to Improve Cancer Therapy
Current Topics in Medicinal Chemistry Sesterterpenoids with Anticancer Activity
Current Medicinal Chemistry Novel Insights Into c-Src
Current Pharmaceutical Design Clinical and Forensic Signs Related to Cocaine Abuse
Current Drug Abuse Reviews Development of Ribonucleotide Reductase Inhibitors: A Review on Structure Activity Relationships
Mini-Reviews in Medicinal Chemistry Imaging Adoptive Cell Transfer Based Cancer Immunotherapy
Current Pharmaceutical Biotechnology Potentials and Challenges of Active Targeting at the Tumor Cells by Engineered Polymeric Nanoparticles
Current Pharmaceutical Biotechnology Defining the Role of Integrin αvβ6 in Cancer
Current Drug Targets Gene Therapy Using IL-12 Family Members in Infection, Auto-Immunity, and Cancer
Current Gene Therapy